ArticleSaudi journal of biological sciences2020
Tobacco smoking causes secondary polycythemia and a mild leukocytosis among heavy smokers in Taif City in Saudi Arabia.
Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Leukocytosis and tobacco use during pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Impact of smoking hookah and cigarettes on hematological and biochemical profiles in the Iranian population.Journal of health, population, and nutrition · 2026Article
- Smoking and liver diseases: an updated review of pathogenesis, progression, and therapeutic implications.Clinical and experimental medicine · 2025Review
- Hidradenitis Suppurativa: Higher Tobacco Pack-Years in Patients with Metabolic Comorbidities.Life (Basel, Switzerland) · 2025Article
- Article
- Editorial: Differential diagnosis of erythrocytosis and analysis of their clinical utility.Frontiers in medicine · 2025Article
- Article
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients.Open medicine (Warsaw, Poland) · 2025Article
- Exploring the potential of selenium nanoparticles and fabricated selenium nanoparticles @vitamin C nanocomposite in mitigating nicotine-induced testicular toxicity in rats.Toxicology research · 2024Article
- COVID-19 Outcome and Tobacco Product Use: Case-Control and Retrospective Cohort Studies Using Nationwide Samples.Journal of Korean medical science · 2024Article
- Predictive Value of Smoking Index Combined with NT-proBNP for Patients with Pulmonary Hypertension Due to Chronic Lung Disease: A Retrospective Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Live to die another day: novel insights may explain the pathophysiology behind smoker's paradox in SARS-CoV-2 infection.Molecular and cellular biochemistry · 2023Review
- Thirdhand vaping exposures are associated with pulmonary and systemic inflammation in a mouse model.Journal of environmental exposure assessment · 2023Article
- Article
- Polycythemia-Related Proliferative Ischemic Retinopathy Managed with Smoking Cessation: A Case Report.International journal of environmental research and public health · 2022Article
- The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radiation.International journal of environmental research and public health · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco smoking is a common risk factor of cardiovascular diseases, cancers and heart health problems. In Taif, the number of secondary polycythemia patients is increasing dramatically and most of those patients are heavy smokers. Therefore, this study is an attempt to understand the pathophysiological mechanism behind that problem. Whole blood and serum samples were collected from forty healthy people and forty tobacco smokers, voluntary for this study. Complete blood counts revealed a significant increase in the red blood cell count, hemoglobin concentrations, hematocrit and neutrophils with some elevations in total white blood cells, lymphocytes and monocytes. Moreover, serum analysis of both erythropoietin and interleukin-7 showed a significant reduction in their levels among smokers which were about 35% and 65% respectively. Gene expression study showed a significant upregulation of RAG-1, RAG-2 and EPOR-1 genes caused by tobacco smoking. In conclusion, data presented in the current study suggest that tobacco smoking might cause alveolar tissue inflammation and vascular injury causing an immune response that elevates the white blood cells count. Another suggestion is that tobacco smoking defects the pulmonary gaseous exchange mechanism leading to the secondary polycythemia indicated by the increase in red blood cell count, hemoglobin levels, hematocrit and by the low serum erythropoietin levels.
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