ArticleSaudi journal of biological sciences2020
Influence of bone mineral density in circulating adipokines among postmenopausal Arab women.
Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Effect of adipokine and ghrelin levels on BMD and fracture risk: an updated systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Association between new anthropometric indices and osteoporosis in Chinese postmenopausal women- retrospective study based on hospitalized patients in China.Frontiers in endocrinology · 2025Article
- Interrelationships among metabolic syndrome, bone-derived cytokines, and the most common metabolic syndrome-related diseases negatively affecting bone quality.Diabetology & metabolic syndrome · 2024Review
- Crosstalk between Lipid Metabolism and Bone Homeostasis: Exploring Intricate Signaling Relationships.Research (Washington, D.C.) · 2024Article
- Research advances in crosstalk between muscle and bone in osteosarcopenia (Review).Experimental and therapeutic medicine · 2023Review
- Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review.Biomedicines · 2023Review
- Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women.Current issues in molecular biology · 2021Article
- Association ofGenes · 2021Article
- PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women.BioMed research international · 2021Article
- Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women.Disease markers · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 ± 0.06, p < 0.00) and resistin (-0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 ± 0.04, p < 0.224) whereas adiponectin remained (-0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.
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Registered trials
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