ArticleSaudi journal of biological sciences2020
Phytochemical profiling, antioxidant and HepG2 cancer cells' antiproliferation potential in the kernels of apricot cultivars.
Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Exploring the phytochemical composition, ethnomedicinal uses, and therapeutic potential of Prunus species: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Mineral Composition, Physicochemical Characteristics, and Antioxidant and Antibacterial Properties of Oil Extracted From Moroccan Bitter Apricot Kernels.Scientifica · 2026Article
- From Waste to Functional Feed Ingredient: Biochemical and SHK-1 Cell Line Evaluation of Black Soldier Fly Larvae for Aquaculture Nutrition.Antioxidants (Basel, Switzerland) · 2025Article
- Phytochemical Profiling and Toxicity Assessment of Aqueous Extract From Bitter Apricot Kernels Cultivated in Morocco.Scientifica · 2025Article
- Article
- The Evaluation of the Phytochemical Profiles and Antioxidant and α-Glucosidase Inhibitory Activities of Four Herbal Teas Originating from China: A Comparative Analysis of Aqueous and Ethanol Infusions.Foods (Basel, Switzerland) · 2024Article
- The immunomodulatory effects of vitamins in cancer.Frontiers in immunology · 2024Review
- Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery.International journal of molecular sciences · 2023Review
- Extracts of Apricot (Animals : an open access journal from MDPI · 2023Article
- New Type of Tannins Identified from the Seeds ofMolecules (Basel, Switzerland) · 2023Article
- Multifunctional and Collaborative Protection of Proteins, Peptides, Phenolic Compounds, and Other Molecules against Oxidation in Apricot Seeds Extracts.Antioxidants (Basel, Switzerland) · 2022Article
- Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells.Molecules (Basel, Switzerland) · 2022Article
- A Review with Updated Perspectives on Nutritional and Therapeutic Benefits of Apricot and the Industrial Application of Its Underutilized Parts.Molecules (Basel, Switzerland) · 2022Review
- Apricot Kernel: Bioactivity, Characterization, Applications, and Health Attributes.Foods (Basel, Switzerland) · 2022Review
- Anticancer Potential and Other Pharmacological Properties ofPlants (Basel, Switzerland) · 2022Review
- Comparative analysis of antioxidant activity, toxicity, and mineral composition of kernel and pomace of apricot (Saudi journal of biological sciences · 2021Article
- Article
- In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae.Saudi journal of biological sciences · 2020Article
- Stone Fruit as Biofactories of Phytochemicals With Potential Roles in Human Nutrition and Health.Frontiers in plant science · 2020Review
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytochemical composition, in vitro antioxidant and antiproliferative activity against HepG2 cells were studied in the kernels of apricot cultivars grown in the northern areas of Pakistan. Relatively, the kernel of Habbi cultivar/AP-12 depicted significant potential to scavenge DPPH and ABTS+ free radicals as well as oxygen radical absorbance capacity along with highest contents of total flavonoids, phenolics, chlorogenic and syringic acids on dry weight basis. The average concentration of quercetin ranged 0.072-1.343 mg/100 g, and of EGCG from 0.713 to 6.521 mg/100 g with maximum concentration in Hulappa/AP-3 and Kho Chali-Khatta 3/AP-17, respectively. Amygdalin content was highest (1145 mg/100 g) in the kernel of Balaani/AP-14. Highest inhibition of HepG2 cells was found in the kernel of Waflu Chuli/AP-9 (EC50 = 15.70 ± 3.77 mg/mL). The PCA showed significant contributions of polyphenols and flavonoids towards biochemical assays, while CA revealed similarities and associations among various cultivars. Our study revealed that Habbi, Waflu Chuli, Thukdeena and Balaani kernels are rich sources of bioactive compounds and possess significant antioxidant and anticancer activity and can contribute considerably in the prevention and treatment of chronic health disorders.
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