Evidence map›Paper›PMID 31889612›Full record

ArticleNuclear medicine and biology

In vitro cytotoxicity of Auger electron-emitting [

Muhamad Faiz Bin Othman, Elise Verger, Ines Costa, Meena Tanapirakgul, Margaret S Cooper, Cinzia Imberti, Valerie J Lewington, Philip J Blower, Samantha Y A Terry

Open access · hybridAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Radiometal chelators for infection diagnostics.Frontiers in nuclear medicine · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. EANM position paper on the role of radiobiology in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2021
    Article
  10. Theranostic Advances in Breast Cancer in Nuclear Medicine.International journal of molecular sciences · 2021
    Review
  11. RetroSPECT: Gallium-67 as a Long-Lived Imaging Agent for Theranostics.Asia Oceania journal of nuclear medicine & biology · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Muhamad Faiz Bin OthmanDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Elise VergerDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Ines CostaDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Meena TanapirakgulDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Margaret S CooperDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Cinzia ImbertiDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Valerie J LewingtonGuy's & St Thomas' NHS Foundation Trust, Kings College London, London SE1 9RT, UK.
Philip J BlowerDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom.
Samantha Y A TerryDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London, SE1 7EH, United Kingdom. Electronic address: samantha.terry@kcl.ac.uk.
St Thomas' Hospital · GBKing's College London · GB

Funding

Wellcome Trust 203148
6 · The paper itself

Abstract

introductionMolecular radiotherapy exploiting short-range Auger electron-emitting radionuclides has potential for targeted cancer treatment and, in particular, is an attractive option for managing micrometastatic disease. Here, an approach using chelator-trastuzumab conjugates to target radioactivity to breast cancer cells was evaluated as a proof-of-concept to assess the suitability of

methodsTHP-trastuzumab and DOTA-trastuzumab were synthesised and radiolabelled with Auger electron-emitters

resultsLabelling efficiencies for [

conclusions[

Indexed as

AutoradiographyCell Line, TumorCell SurvivalElectronsGallium RadioisotopesHumansIsotope LabelingTrastuzumabGallium-67Gallium RadioisotopesTrastuzumabAuger electronsGallium-67Molecular radiotherapyRadiobiologyTrastuzumabTris(hydroxypyridinone)

Identifiers

PMID31889612
PMCPMC7099941
OpenAlexW2994676495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.