ArticleAnais brasileiros de dermatologia
Is macular lymphocytic arteritis limited to the skin? Long-term follow-up of seven patients.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Macular arteritis in an HIV-infected patient improving with adherence to antiretroviral therapy.JAAD case reports · 2020Article
- Update on vasculitis: overview and relevant dermatological aspects for the clinical and histopathological diagnosis - Part II.Anais brasileiros de dermatologiaReview
- Serologic Abnormalities in Macular Lymphocytic Arteritis with Case Presentation.Case reports in dermatologyArticle
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3 authors at 2 institutions in 1 country.
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Abstract
backgroundMacular lymphocytic arteritis most commonly presents as hyperpigmented macules on the lower limbs. The pathogenesis of this disease is still unclear and there is an ongoing debate regarding whether it represents a new form of cutaneous vasculitis or an indolent form of cutaneous polyarteritis nodosa.
objectiveTo describe clinical, histopathological, and laboratory findings of patients with the diagnosis of macular lymphocytic arteritis.
methodsA retrospective search was conducted by reviewing cases followed at the Vasculitis Clinic of the Dermatology Department, School of Medicine, University of São Paulo, between 2005 and 2017. Seven patients were included.
resultsAll cases were female, aged 9-46 years, and had hyperpigmented macules mainly on the legs. Three patients reported symptoms. Skin biopsies evidencing a predominantly lymphocytic infiltrate affecting arterioles at the dermal subcutaneous junction were found, as well as a typical luminal fibrin ring. None of the patients developed necrotic ulcers, neurological damage, or systemic manifestations. The follow-up ranged from 18 to 151 months, with a mean duration of 79 months. STUDY LIMITATIONS: This study is subject to a number of limitations: small sample of patients, besides having a retrospective and uncontrolled study design.
conclusionsTo the best of the authors' knowledge, this series presents the longest duration of follow-up reported to date. During this period, none of the patients showed resolution of the lesions despite treatment, nor did any progress to systemic vasculitis. Similarities between clinical and skin biopsy findings support the hypothesis that macular lymphocytic arteritis is a benign, incomplete, and less aggressive form of cutaneous polyarteritis nodosa.
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