ArticleThe American journal of tropical medicine and hygiene2020
Environmental Predictors of Schistosomiasis Persistent Hotspots following Mass Treatment with Praziquantel.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Challenges in Protocol Development and Interpretation of the Schistosomiasis Consortium for Operational Research and Evaluation Intervention Studies.The American journal of tropical medicine and hygiene · 2020Trial
- Biomphalaria pfeifferi infected with Schistosoma spp. in Kakamega and Bungoma counties, western Kenya confirms autochthonous transmission of intestinal schistosomiasis.PLoS neglected tropical diseases · 2026Article
- Pharos: a mobile GIS application for network assessment and ground-truth mapping to support mHealth study design in low-resource settings.International journal of geographical information science : IJGIS · 2026Article
- Schistosomiasis amongst adolescent boys in non-lakeshore southern Malawi: Investigating local risk-factors within a nested community-based cross-sectional survey.PLoS neglected tropical diseases · 2025Article
- Identifying key aspects to enhance predictive modeling for early identification of schistosomiasis hotspots to guide mass drug administration.PLoS neglected tropical diseases · 2025Article
- Diterpenoids with Schistosomula-Killing and Anti-Fibrosis Activities In Vitro from the Leaves ofMolecules (Basel, Switzerland) · 2024Article
- Schistosoma Infection Burden and Risk Factors among School-Aged Children in a Rural Area of the Democratic Republic of the Congo.Tropical medicine and infectious disease · 2023Article
- Open-source environmental data as an alternative to snail surveys to assess schistosomiasis risk in areas approaching elimination.International journal of health geographics · 2023Article
- Open-source environmental data as an alternative to snail surveys to assess schistosomiasis risk in areas approaching elimination.Research square · 2023Article
- Predictive Risk Mapping of Schistosomiasis in Madagascar Using Ecological Niche Modeling and Precision Mapping.Tropical medicine and infectious disease · 2022Article
- ABO Blood Groups Do Not PredictMicroorganisms · 2021Article
- Exposure, hazard, and vulnerability all contribute to Schistosoma haematobium re-infection in northern Senegal.PLoS neglected tropical diseases · 2021Article
- Schistosome infection in Senegal is associated with different spatial extents of risk and ecological drivers for Schistosoma haematobium and S. mansoni.PLoS neglected tropical diseases · 2021Article
- Effectiveness of mass treatment of Schistosoma mansoni infection in socially vulnerable areas of a state in northeastern Brazil, 2011-2014.Archives of public health = Archives belges de sante publique · 2021Article
- Molecular Tools and Schistosomiasis Transmission Elimination.The American journal of tropical medicine and hygiene · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis control programs rely heavily on mass drug administration (MDA) campaigns with praziquantel for preventative chemotherapy. Areas where the prevalence and/or intensity of schistosomiasis infection remains high even after several rounds of treatment, termed "persistent hotspots" (PHSs), have been identified in trials of MDA effectiveness conducted by the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) in Kenya, Mozambique, Tanzania, and Côte d'Ivoire. In this analysis, we apply a previously developed set of criteria to classify the PHS status of 531 study villages from five SCORE trials. We then fit logistic regression models to data from SCORE and publically available georeferenced datasets to evaluate the influence of local environmental and population features, pre-intervention infection burden, and treatment scheduling on PHS status in each trial. The frequency of PHS in individual trials ranged from 35.3% to 71.6% in study villages. Significant relationships between PHS status and MDA frequency, distance to freshwater, rainfall, baseline schistosomiasis burden, elevation, land cover type, and village remoteness were each observed in at least one trial, although the strength and direction of these relationships was not always consistent among study sites. These findings suggest that PHSs are driven in part by environmental conditions that modify the risk and frequency of reinfection.
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Registered trials
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