ArticleJournal of the American Geriatrics Society2020
Gray Matter Regions Associated With Functional Mobility in Community-Dwelling Older Adults.
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Dementia with Lewy bodies and gait neural basis: a cross-sectional study.Alzheimer's research & therapy · 2024Trial
- Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults.Human brain mapping · 2023Trial
- Overweight/obesity and gait abnormality: what role does the brain play in the relationship?International journal of obesity (2005) · 2026Article
- Associations between connectivity in functional brain networks and gait speed in older adults with and without multiple sclerosis.Journal of neurology · 2025Article
- Gait Variability Is Associated With Gray Matter Volumes Implicated in Cognitive Function: A Cross-Sectional Analysis From the AGUEDA Trial.Innovation in aging · 2025Article
- Machine Learning for Movement Pattern Changes during Kinect-Based Mixed Reality Exercise Programs in Women with Possible Sarcopenia: Pilot Study.Annals of geriatric medicine and research · 2024Article
- Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Bidirectional mediation of bone mineral density and brain atrophy on their associations with gait variability.Scientific reports · 2024Article
- Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.BMC geriatrics · 2024Article
- Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions.Aging and disease · 2024Review
- The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial.Journal of Alzheimer's disease reports · 2024Article
- Challenges and opportunity in mobility among older adults - key determinant identification.BMC geriatrics · 2023Review
- Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility.Frontiers in aging neuroscience · 2022Article
- Participation in cognitive activities is associated with foot reaction time and gait speed in older adults.Aging clinical and experimental research · 2021Article
- Neural correlates of walking post-stroke: neuroimaging insights from the past decade.Experimental brain research · 2021Review
- Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults.Frontiers in nutrition · 2021Article
- Regional Gray Matter Density Associated With Fast-Paced Walking in Older Adults: A Voxel-Based Morphometry Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesNeuroimaging indicators of reduced brain health in the form of lower gray matter volume (GMV), lower fractional anisotropy (FA), and higher white matter hyperintensity volume (WMHV) have been related to global mobility measures, such as gait speed, in older adults. The purpose was to identify associations between brain regions and specific mobility functions to provide a greater understanding of the contribution of the central nervous system to independent living.
designCross-sectional study.
settingResearch laboratory.
participantsSeventy community-ambulating healthy older adults (mean age = 76 ± 5 years). MEASUREMENTS: Participants performed the following tests: gait speed, Five Times Sit to Stand, Four Square Step Test (FSST), and Dynamic Gait Index (DGI). Structural magnetic resonance imaging of each participant's brain was collected. Measures of regional GMV, tract-specific WMHV, and FA were extracted. Correlational analyses between the mobility measures and neuroimaging measures were conducted using whole brain and regional and tract-specific measures. This was followed by linear regression models relating the mobility measures to regions or tracts identified in the correlation analysis, and adjusting for age, sex, and body mass index.
resultsSignificant associations were found between higher GMV in multiple regions, primarily the parietal and temporal lobes, and better performance in gait speed, DGI, and FSST. After adjusting for personal factors, greater parahippocampus GMV was independently associated with greater gait speed. Greater inferior parietal lobe, supramarginal gyrus, and superior temporal gyrus GMVs were associated with gait function. Greater postcentral gyrus, parahippocampus, and superior temporal gyrus GMVs were associated with faster FSST performance. The WMHV and FA were not significantly correlated with the mobility measures.
conclusionsGray matter regions associated with higher performance in mobility measures serving gait function and multidirectional stepping were those structures related to vestibular sensation, spatial navigation, and somatosensation. J Am Geriatr Soc 68:1023-1028, 2020.
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