Evidence map›Paper›PMID 31889168›Full record

ArticleScientific reports2019

Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms.

Andreas Vollmer, Ali Al-Ahmad, Aikaterini Argyropoulou, Thomas Thurnheer, Elmar Hellwig, Thomas Attin, Kirstin Vach, Annette Wittmer, Kerry Ferguson, Alexios Leandros Skaltsounis and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Andreas VollmerDepartment of Operative Dentistry and Periodontology, Center for Dental Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Ali Al-AhmadDepartment of Operative Dentistry and Periodontology, Center for Dental Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Aikaterini ArgyropoulouDepartment of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Thomas ThurnheerClinic for Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8615-8209
Elmar HellwigDepartment of Operative Dentistry and Periodontology, Center for Dental Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Thomas AttinClinic for Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Kirstin VachInstitute for Medical Biometry and Statistics, Center for Medical Biometry and Medical Informatics, Albert-Ludwigs-University, Freiburg, Germany.
Annette WittmerInstitute of Medical Microbiology and Hygiene, Albert-Ludwigs-University, Freiburg, Germany.
Kerry FergusonBotanical Innovation, Unit 2, 390 Clergate Road, Orange, NSW, 2800, Australia.
Alexios Leandros SkaltsounisDepartment of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Lamprini KarygianniClinic for Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland. lamprini.karygianni@zzm.uzh.ch.ORCID http://orcid.org/0000-0002-7893-0393
University of Freiburg · DEUniversity of Zurich · CHNational and Kapodistrian University of Athens · GRInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to increasing antibiotic resistance, the application of antimicrobial photodynamic therapy (aPDT) is gaining increasing popularity in dentistry. The aim of this study was to investigate the antimicrobial effects of aPDT using visible light (VIS) and water-filtered infrared-A (wIRA) in combination with a Hypericum perforatum extract on in situ oral biofilms. The chemical composition of H. perforatum extract was analyzed using ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry (UPLC-HRMS). To obtain initial and mature oral biofilms in situ, intraoral devices with fixed bovine enamel slabs (BES) were carried by six healthy volunteers for two hours and three days, respectively. The ex situ exposure of biofilms to VIS + wIRA (200 mWcm

Indexed as

Infrared RaysLightAnti-Infective AgentsBacteriaBacterial AdhesionBiofilmsChromatography, High Pressure LiquidHumansHypericumMicrobial ViabilityMouth MucosaPhytochemicalsPlant ExtractsSpectrometry, Mass, Electrospray IonizationAnti-Infective AgentsPhytochemicalsPlant Extracts

Identifiers

PMID31889168
PMCPMC6937260
OpenAlexW2996975369

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.