ArticleScientific reports2019
Age-related changes of individual macular retinal layers among Asians.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Explainable Multimodal OCT and OCTA Analysis Reveals Structural and Vascular Features of Mild Glaucoma Across Ethnicities.Investigative ophthalmology & visual science · 2026Observational
- SYN-OCT:A synthetic dataset of ocular optical coherence tomography images from healthy and glaucoma eyes.Scientific data · 2026Article
- An Evaluation of the Retinal Nerve Fibre Layer and Ganglion Cell Layer Thickness in Low Myopes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Observational
- Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Photoreceptor layer thinning is an early biomarker for type 2 diabetes: a cohort study in UK Biobank.Eye (London, England) · 2025Article
- Design and application of a realistic and multifunctional retinal phantom for standardizing ophthalmic imaging systems.Communications engineering · 2025Article
- Retinal nerve fiber layer thickness profile in an Iranian adult population.Scientific reports · 2025Article
- Macular, choroidal and disc associations across women's reproductive life stages: a scoping review from menarche to post-menopause.Eye (London, England) · 2025Article
- Retinal thickness predicts the risk of cognitive decline over five years.Alzheimer's research & therapy · 2024Article
- Lifelong Changes in the Choroidal Thickness, Refractive Status, and Ocular Dimensions in C57BL/6J Mouse.Investigative ophthalmology & visual science · 2024Article
- Evaluation of thickness of individual macular retinal layers in diabetic eyes from optical coherence tomography.Scientific reports · 2024Article
- Intervisit Reproducibility of Foveal Cone Density Metrics.Translational vision science & technology · 2024Article
- Secreted in Xylem (SIX) genes in Fusarium oxysporum f.sp. cubense (Foc) unravels the potential biomarkers for early detection of Fusarium wilt disease.Archives of microbiology · 2024Article
- Reduced Thickness of the Retina in de novo Parkinson's Disease Shows A Distinct Pattern, Different from Glaucoma.Journal of Parkinson's disease · 2024Article
- Macular thickness and its associated factors in a Chinese rural adult population: the Handan Eye Study.The British journal of ophthalmology · 2023Article
- Article
- Retinal Thickness and Its Interocular Asymmetry Between Parkinson's Disease and Drug-Induced Parkinsonism.Journal of Korean medical science · 2023Article
- Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building.BMJ open · 2023Article
- Assessing the external validity of machine learning-based detection of glaucoma.Scientific reports · 2023Article
- Differentiation of the retinal morphology aging trajectories in schizophrenia and their associations with cognitive dysfunctions.Frontiers in psychiatry · 2023Article
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14 authors.
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Abstract
We characterized the age-related changes of the intra-retinal layers measured with spectral-domain optical coherence tomography (SD-OCT; Cirrus high-definition OCT [Carl Zeiss Meditec]. The Singapore Epidemiology of Eye Diseases is a population-based, cross-sectional study of Chinese, Malays and Indians living in Singapore. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used for intra-retinal layer segmentation and mean thickness of 10 intra-retinal layers rescaled with magnification correction using axial length value. Linear regression models were performed to investigate the association of retinal layers with risk factors. After excluding participants with history of diabetes or ocular diseases, high-quality macular SD-OCT images were available for 2,047 participants (44-89 years old). Most of the retinal layers decreased with age except for foveal retinal nerve fiber layer (RNFL) and the inner/outer segments of photoreceptors where they increased with age. Men generally had thicker retinal layers than women. Chinese have the thickest RNFL and retinal pigment epithelium amongst the ethnic groups. Axial length and refractive error remained correlated with retinal layers in spite of magnification correction. Our data show pronounced age-related changes in retinal morphology. Age, gender, ethnicity and axial length need be considered when establishing OCT imaging biomarkers for ocular or systemic disease.
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