ArticleScientific reports2019
Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Predominant miRNAs in Animal-Source Foods and Bioinformatic Analysis.Current issues in molecular biology · 2026Article
- Bta-miR-30f promotes adipogenesis and unsaturated fatty acid accumulation by targetingiScience · 2026Article
- Exploring the role of food-source microRNAs as potential nutritional bioactives in humans.NPJ science of food · 2026Article
- Goat and cow-milk based infant formulas contain extracellular vesicles with different miRNA and protein cargo.Current research in food science · 2026Article
- Article
- Article
- Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties.Frontiers in nutrition · 2025Review
- Comparative miRNome analysis of colostrum- and mature milk-derived extracellular vesicles from Holstein and Jersey cows.Journal of animal science and technology · 2025Article
- Comparison of miR-106b, miR-191, and miR-30d expression dynamics in milk with regard to its composition in Holstein and Ayrshire cows.Animal bioscience · 2024Article
- The absorption of bovine milk small extracellular vesicles largely depends on galectin 3 and galactose ligands in human intestinal cells and C57BL/6J mice.American journal of physiology. Cell physiology · 2023Article
- MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows.BMC genomics · 2023Article
- Effects of Cow's Milk Processing on MicroRNA Levels.Foods (Basel, Switzerland) · 2023Article
- Review: Milk Small Extracellular Vesicles for Use in the Delivery of Therapeutics.Pharmaceutical research · 2023Review
- Regulation of adipogenesis by exosomal milk miRNA.Reviews in endocrine & metabolic disorders · 2023Review
- Genetic polymorphism of prolactin and nitric oxide synthase in Holstein cattle.Veterinary world · 2023Article
- Differences in the microRNAs Levels of Raw Milk from Dairy Cattle Raised under Extensive or Intensive Production Systems.Veterinary sciences · 2022Article
- Exosomes in Mastitis-Research Status, Opportunities, and Challenges.Animals : an open access journal from MDPI · 2022Review
- Variation of miRNA Content in Cow Raw Milk Depending on the Dairy Production System.International journal of molecular sciences · 2022Article
- Milk exosomes in nutrition and drug delivery.American journal of physiology. Cell physiology · 2022Review
- Bovine mammary alveolar MAC-T cells afford a tool for studies of bovine milk exosomes in drug delivery.International journal of pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the stages of lactation. Here, we have studied the variation in milk microRNA composition according to genetic background. Using high throughput sequencing, we have characterized and compared the milk miRNomes of Holstein and Normande cattle, dairy breeds with distinct milk production features, in order to highlight microRNAs that are essential for regulation of the lactation process. In Holstein and Normande milk, 2,038 and 2,030 microRNAs were identified, respectively, with 1,771 common microRNAs, of which 1,049 were annotated and 722 were predicted. The comparison of the milk miRNomes of two breeds allowed to highlight 182 microRNAs displaying significant differences in the abundance. They are involved in the regulation of lipid metabolism and mammary morphogenesis and development, which affects lactation. Our results provide new insights into the regulation of molecular mechanisms involved in milk production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.