Evidence map›Paper›PMID 31889006›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY.

Xiaoxu Jiang, Natalia Ermolova, John Lim, Seo Woo Choi, H Ronald Kaback

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Membrane Chemistry Tunes the Structure of a Peptide Transporter.Angewandte Chemie (International ed. in English) · 2020
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaoxu JiangDepartment of Physiology, University of California, Los Angeles, CA 90095.
Natalia ErmolovaDepartment of Physiology, University of California, Los Angeles, CA 90095.
John LimDepartment of Physiology, University of California, Los Angeles, CA 90095.
Seo Woo ChoiDepartment of Physiology, University of California, Los Angeles, CA 90095.
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, CA 90095; rkaback@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

LacY catalyzes accumulation of galactosides against a concentration gradient by coupling galactoside and H

Indexed as

ProtonsBinding SitesBiological TransportGalactosidesHydrogen-Ion ConcentrationIon TransportKineticsLactoseMembrane PotentialsMembrane Transport ProteinsModels, MolecularGalactosidesLactoselactose permeaseMembrane Transport ProteinsProtonseffluxmembrane proteinsmembranespermeasetransport

Identifiers

PMID31889006
PMCPMC6969543
OpenAlexW2997841789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.