ArticleProceedings of the National Academy of Sciences of the United States of America2020
Variable functional connectivity architecture of the preterm human brain: Impact of developmental cortical expansion and maturation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Infant social interactions and brain development: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Robust probabilistic measurement of structural-functional module consistency in infant brain development.Brain structure & function · 2026Article
- Functional connectivity patterns as an early indicator of later very early preterm outcomes.Developmental cognitive neuroscience · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Convergent and divergent brain-cognition development in early adolescence.Nature communications · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Impact of touch interventions on brain activity in moderately preterm infants: study protocol for a pilot randomised controlled trial.BMJ open · 2025Article
- Edge participation coefficient unveiling the developmental dynamics of neonatal functional connectome.Communications biology · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Cortical representational geometry of diverse tasks reveals subject-specific and subject-invariant cognitive structures.Communications biology · 2025Article
- Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder.Psychological medicine · 2025Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- Denoising strategies of functional connectivity MRI data in lesional and non-lesional brain diseases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Local Gradients of Functional Connectivity Enable Precise Fingerprinting of Infant Brains During Dynamic Development.bioRxiv : the preprint server for biology · 2024Article
- Brain age prediction and deviations from normative trajectories in the neonatal connectome.Nature communications · 2024Article
- Prenatal environment is associated with the pace of cortical network development over the first three years of life.Nature communications · 2024Article
- Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents.Psychiatry and clinical neurosciences · 2024Article
- Constructing fine-grained spatiotemporal neonatal functional atlases with spectral functional network learning.Human brain mapping · 2024Article
- Delineating morbidity patterns in preterm infants at near-term age using a data-driven approach.BMC pediatrics · 2024Article
- Individual differences in the neural architecture in semantic processing.Scientific reports · 2024Article
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
Abstract
Functional connectivity (FC) is known to be individually unique and to reflect cognitive variability. Although FC can serve as a valuable correlate and potential predictor of (patho-) physiological nervous function in high-risk constellations, such as preterm birth, templates for individualized FC analysis are lacking, and knowledge about the capacity of the premature brain to develop FC variability is limited. In a cohort of prospectively recruited, preterm-born infants undergoing magnetic resonance imaging close to term-equivalent age, we show that the overall pattern could be reliably detected with a broad range of interindividual FC variability in regions of higher-order cognitive functions (e.g., association cortices) and less interindividual variability in unimodal regions (e.g., visual and motor cortices). However, when comparing the preterm and adult brains, some brain regions showed a marked shift in variability toward adulthood. This shift toward greater variability was strongest in cognitive networks like the attention and frontoparietal networks and could be partially predicted by developmental cortical expansion. Furthermore, FC variability was reflected by brain tissue characteristics indicating cortical maturation. Brain regions with high functional variability (e.g., the inferior frontal gyrus and temporoparietal junction) displayed lower cortical maturation at birth compared with somatosensory cortices. In conclusion, the overall pattern of interindividual variability in FC is already present preterm; however, some brain regions show increased variability toward adulthood, identifying characteristic patterns, such as in cognitive networks. These changes are related to postnatal cortical expansion and maturation, allowing for environmental and developmental factors to translate into marked individual differences in FC.
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