ArticleeNeuro
Evaluating the Burstlet Theory of Inspiratory Rhythm and Pattern Generation.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Noradrenergic neuromodulation produces a NMDAR-dependent network state of respiratory rhythmogenesis in the preBötzinger Complex.bioRxiv : the preprint server for biology · 2026Article
- Review
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- A Computational Model of the Respiratory CPG for the Artificial Control of Breathing.Bioengineering (Basel, Switzerland) · 2025Article
- Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination.NAM journal · 2025Article
- The road toward a physiological control of artificial respiration: the role of bio-inspired neuronal networks.Frontiers in neuroscience · 2025Article
- Interdependence of cellular and network properties in respiratory rhythm generation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex.The Journal of physiology · 2024Article
- Interdependence of cellular and network properties in respiratory rhythmogenesis.bioRxiv : the preprint server for biology · 2023Article
- Role of NaCell reports · 2023Article
- Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Single cell transcriptome sequencing of inspiratory neurons of the preBötzinger complex in neonatal mice.Scientific data · 2022Article
- Breathing Rhythm and Pattern and Their Influence on Emotion.Annual review of neuroscience · 2022Review
- Inspiratory rhythm generation is stabilized byJournal of neurophysiology · 2022Article
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
- Article
- Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice.Scientific reports · 2022Article
- Phase- and state-dependent modulation of breathing pattern by preBötzinger complex somatostatin expressing neurons.The Journal of physiology · 2022Article
- Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network.eLife · 2021Article
- Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.Journal of neurophysiology · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The preBötzinger complex (preBötC) generates the rhythm and rudimentary motor pattern for inspiratory breathing movements. Here, we test "burstlet" theory (Kam et al., 2013a), which posits that low amplitude burstlets, subthreshold from the standpoint of inspiratory bursts, reflect the fundamental oscillator of the preBötC. In turn, a discrete suprathreshold process transforms burstlets into full amplitude inspiratory bursts that drive motor output, measurable via hypoglossal nerve (XII) discharge
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.