Evidence map›Paper›PMID 31888882›Full record

Trial reportDrug metabolism and disposition: the biological fate of chemicals2020

Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.

Kimberly S Collins, Ingrid F Metzger, Brandon T Gufford, Jessica B Lu, Elizabeth B Medeiros, Victoria M Pratt, Todd C Skaar, Zeruesenay Desta

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kimberly S CollinsDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-4978-4593
Ingrid F MetzgerDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Brandon T GuffordDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Jessica B LuDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Elizabeth B MedeirosDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Victoria M PrattDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Todd C SkaarDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Zeruesenay DestaDepartment of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana zdesta@iu.edu.
Indiana University School of Medicine

Funding

Indiana University Comprehensive Training in Clinical PharmacologyT32GM008425 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Zeruesenay Desta, Michael Thomas Eadon · 1992 to 2026
$7.7M
Regulation of drug metabolizing enzymes by miRNAsR01GM088076 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SKAAR, TODD C. · 2009 to 2017
$3.8M
CYP2B6 Genetic Variations and Drug InteractionsR01GM078501 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DESTA, ZERUESENAY · 2007 to 2015
$3.2M
MIRA-Regulation of drug metabolizing enzymesR35GM131812 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SKAAR, TODD C. · 2019 to 2023
$2.5M
Mechanisms Underlying Stereoselective Bupropion Metabolism and Complex Drug Interactions.R01GM121707 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI DESTA, ZERUESENAY · 2017 to 2020
$1.5M
Age-related changes in microRNA expression effect on drug metabolism in human liverF31GM119401 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI COLLINS, KIMBERLY S. · 2016 to 2017
$40k
NIGMS NIH HHS F31 GM119401NIGMS NIH HHS R01 GM078501NIGMS NIH HHS R01 GM088076NIGMS NIH HHS R01 GM121707NIGMS NIH HHS R35 GM131812NIGMS NIH HHS T32 GM008425
6 · The paper itself

Abstract

Chronic administration of efavirenz is associated with decreased serum bilirubin levels, probably through induction of

Indexed as

AdolescentAdultAlkynesATP-Binding Cassette, Sub-Family C ProteinsBenzoxazinesBilirubinCyclopropanesFemaleGenotypeGlucuronosyltransferaseHealthy VolunteersHumansLiver-Specific Organic Anion Transporter 1MaleMiddle AgedMultidrug Resistance-Associated Protein 2AlkynesATP-Binding Cassette, Sub-Family C ProteinsBenzoxazinesBilirubinCyclopropanesefavirenzGlucuronosyltransferaseLiver-Specific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2SLCO1B1 protein, humanUGT1A1 Enzyme

Identifiers

PMID31888882
PMCPMC7011111
OpenAlexW2997444111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.