ArticleCritical care (London, England)2019
Non-pulsatile blood flow is associated with enhanced cerebrovascular carbon dioxide reactivity and an attenuated relationship between cerebral blood flow and regional brain oxygenation.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03732651 (The Impact of Non-pulsatile Perfusion on Cerebral Blood Flow and Brain Oxygenation), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Non-pulsatile Perfusion on Cerebral Blood Flow and Brain Oxygenation
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The impact of hyperventilation on seizure duration following electroconvulsive therapy: a systematic review and meta-analysis of randomized trials.BMC psychiatry · 2025Pooled it
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.British journal of anaesthesia · 2025Guideline
- Neuroimaging and Neuropathologic Findings in Pediatric Patients with ECMO: An Imaging-Pathology Comparison.Neurocritical care · 2026Article
- Neuroprognostication After Extracorporeal Cardiopulmonary Resuscitation: ECMO-Specific Challenges and a Multimodal Time-Sensitive Framework.Journal of cardiovascular development and disease · 2026Review
- Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices.Journal of stroke · 2026Review
- Delirium after coronary artery bypass grafting with cardiopulmonary bypass surgery: The value of cerebral autoregulation.Perfusion · 2026Article
- Correlation Between Neuroimaging and Neuropathologic Findings in Pediatric ECMO Patients.Research square · 2026Article
- A case report of cardiogenic shock with transcranial color-coded ultrasound monitoring under ECMO.Frontiers in cardiovascular medicine · 2026Article
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Pulse Pressure and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Preclinical Proof-of-Concept of a Minimally Invasive Direct Cardiac Compression Device for Pediatric Heart Support.Cardiovascular engineering and technology · 2024Article
- A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment.APL bioengineering · 2024Article
- Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.Biomedical optics express · 2024Article
- Changes in autonomic function and cerebral and somatic oxygenation with arterial flow pulsatility for children requiring veno-arterial extracorporeal membrane oxygenation.Brain & spine · 2024Article
- Neuromonitoring During ECMO Support in Children.Neurocritical care · 2023Review
- Concurrent subarachnoid haemorrhage and internal carotid artery dissection: a transcranial colour-coded sonography diagnosis.Journal of ultrasound · 2023Article
- Article
- Blood-brain barrier dysfunction in intensive care unit.Journal of intensive medicine · 2023Review
- Characterization of Cerebral Hemodynamics with TCD in Patients Undergoing VA-ECMO and VV-ECMO: a Prospective Observational Study.Neurocritical care · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated in neurological complications. Furthermore, the adverse effects of absent pulsatility on the cerebral microcirculation are modulated similarly as CO
methodsIn this prospective, single-centre case-control trial, we studied 32 patients undergoing elective cardiac surgery. Blood flow velocity in the middle cerebral artery (MCAv) as well as rSO
resultsMCAv was generally lower during hypocapnia than during normocapnia and hypercapnia (p < 0.0001). However, the MCAv/PaCO
conclusionsNon-pulsatile perfusion is associated with enhanced cerebrovascular CVR resulting in greater relative decreases of cerebral blood flow during hypocapnia. Heterogenic microvascular perfusion may account for the attenuated ΔrSO
trial registrationThe study was retrospectively registered on October 30, 2018, with Clinical Trial.gov (NCT03732651).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.