Evidence map›Paper›PMID 31888709›Full record

ArticleTrials2019

A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) - A Protocol.

Rupinder K Bajwa, Sarah E Goldberg, Veronika Van der Wardt, Clare Burgon, Claudio Di Lorito, Maureen Godfrey, Marianne Dunlop, Pip Logan, Tahir Masud, John Gladman and 11 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  18. Cognitive Resilience in Brain Health and Dementia Research.Journal of Alzheimer's disease : JAD · 2022
    Review
  19. Article
  20. Tele-Rehabilitation for People with Dementia during the COVID-19 Pandemic: A Case-Study from England.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Rupinder K BajwaDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK. Rupinder.Bajwa@nottingham.ac.uk.ORCID http://orcid.org/0000-0002-9551-2409
Sarah E GoldbergSchool of Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
Veronika Van der WardtDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Clare BurgonDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Claudio Di LoritoDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Maureen GodfreyPatient and Public Involvement Collaborator, Nottingham, UK.
Marianne DunlopPatient and Public Involvement Collaborator, Nottingham, UK.
Pip LoganDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Tahir MasudDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
John GladmanDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Helen SmithMental Health Services for Older People, Nottinghamshire Healthcare NHS Foundation Trust, Highbury Hospital, Nottingham, NG6 9RD, UK.
Vicky Hood-MooreSchool of Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
Vicky BoothDivison of Rehabilitation, Ageing and Wellbeing, University of Nottingham, Nottingham, NG7 2UH, UK.
Roshan Das NairInstitute of Mental Health, University of Nottingham, Nottingham, NG8 1BB, UK.
Kristian PollockSchool of Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
Kavita VedharaDivision of Primary Care, University of Nottingham, Nottingham, NG7 2RD, UK.
Rhiannon Tudor EdwardsCentre for Health Economics and Medicines Evaluation, Bangor University, Bangor, LL57 2PZ, UK.
Carys JonesCentre for Health Economics and Medicines Evaluation, Bangor University, Bangor, LL57 2PZ, UK.
Zoe HoareNorth Wales Organisation for Randomised Trials in Health Clinical Trials Unit (NWORTH CTU), Bangor University, Bangor, LL57 2PZ, Wales, UK.
Andrew BrandNorth Wales Organisation for Randomised Trials in Health Clinical Trials Unit (NWORTH CTU), Bangor University, Bangor, LL57 2PZ, Wales, UK.
Rowan H HarwoodSchool of Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
University of Nottingham · GBBangor University · GBNottingham University Hospitals NHS Trust · GBNottinghamshire Healthcare NHS Foundation Trust · GB

Funding

Department of Health RP-PG-0614-20007Programme Grants for Applied Research RP-PG-0614-20007
6 · The paper itself

Abstract

backgroundPeople with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.

methodsWe will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective. DISCUSSION: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.

trial registrationISRCTN, ISRCTN15320670. Registered on 4 September 2018.

Indexed as

Cognitive DysfunctionDementiaExercise TherapyIndependent LivingAccidental FallsAgedAged, 80 and overCaregiversCost-Benefit AnalysisDelivery of Health CareExerciseFeasibility StudiesFemaleFollow-Up StudiesHumansMaleActivities of daily livingBalance trainingCognitive impairmentDementiaDual-task trainingFalls preventionOccupational therapyPhysiotherapyStrength trainingTailoring

Identifiers

PMID31888709
PMCPMC6937783
OpenAlexW2997003692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.