ArticleBMC women's health2019
Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis?
Article in BMC women's health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association of platelets and platelet-related parameters (PLT/MPV/PLR) in endometriosis: a meta-analysis.BMC women's health · 2026Pooled it
- Neutrophil-to-lymphocyte ratio and endometriosis: systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Observational
- Clinical value of clinical symptoms, serum biomarkers, and coagulation parameters for ovarian endometrioma diagnosis.Journal of ovarian research · 2026Article
- The Fibrinogen-to-Albumin Ratio in Endometriosis: A Step Toward Personalized Non-Invasive Diagnostics.Journal of personalized medicine · 2026Article
- Associations between aggregate index of systemic inflammation and endometriosis risk utilizing logistic regression analysis.Frontiers in medicine · 2026Article
- Plasma fibrinogen levels in women with infertility undergoing surgical evaluation for endometriosis: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Can hematological and biochemical parameters clinically predict the diagnosis of deep infiltrating endometriosis?BMC women's health · 2025Article
- Article
- Endometriosis: An Immunologist's Perspective.International journal of molecular sciences · 2025Review
- Comparison of serum markers of inflammation in endometrioma and benign ovarian cysts.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Application of machine learning techniques in the diagnosis of endometriosis.BMC women's health · 2024Article
- The coagulation status in women of endometriosis with stage IV.BMC women's health · 2024Article
- The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model.European journal of obstetrics & gynecology and reproductive biology: X · 2024Article
- A stacked machine learning-based classification model for endometriosis and adenomyosis: a retrospective cohort study utilizing peripheral blood and coagulation markers.Frontiers in digital health · 2024Article
- Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis.Journal of multidisciplinary healthcare · 2024Article
- Assessment of Risk Factors Associated with Severe Endometriosis and Establishment of Preoperative Prediction Model.Diagnostics (Basel, Switzerland) · 2022Article
- Anemia-Associated Platelets and Plasma Prothrombin Time Increase in Patients with Adenomyosis.Journal of clinical medicine · 2022Article
- The Search for Biomarkers in Endometriosis: a Long and Windy Road.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis is defined as a chronic inflammatory disease. Recent studies have shown that increased coagulation parameters including fibrinogen and platelets are associated with endometriosis. The objective of this study was to determine the levels of inflammatory markers and coagulation parameters and their correlations in women with endometriomas compared to those with benign ovarian cysts or normal pelvic anatomy.
methodsBetween June 2015 and June 2017, a total of 548 women who underwent laparoscopic/laparotomic surgery for ovarian endometriomas (OMA group, n = 226), non-endometriosis benign ovarian cysts (Cyst group, n = 210) and tubal reanastomosis (Control group, n = 112) were recruited in this study. Inflammatory markers including c-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and coagulation parameters including platelet count, thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time, and plasma fibrinogen as well as CA-125 were determined.
resultsCompared with Cyst group and Control group, TT and PT in OMA group were significantly shorter and plasma fibrinogen levels were significantly higher (P < 0.05). Moreover, the levels of plasma fibrinogen were positively correlated with CRP, NLR and PLR (P < 0.05). In addition, the confidence intervals for the area under the curve (AUC) for CA-125 × fibrinogen were significantly higher than those for CA-125 (0.904-0.952 vs. 0.899-0.949) in the diagnosis of endometrioma.
conclusionsThese results indicate that women with endometriomas demonstrate a hypercoagulable status due to the inflammatory nature of endometriosis. The combined determination for CA-125 and fibrinogen demonstrate a higher area under the curve than the single detection of CA-125 in those with endometriomas compared to these with benign ovarian cysts.
trial registrationThis study was approved by the Human Ethics Committee of the Women's Hospital, School of Medicine, Zhejiang University (No.20170174) and all women provided written informed consent.
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