ArticleBMC pregnancy and childbirth2019
Group B Streptococcus detection in pregnant women: comparison of qPCR assay, culture, and the Xpert GBS rapid test.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Screening forBio-protocol · 2025Article
- Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study.Infection · 2025Article
- Screening of Group BOpen medicine (Warsaw, Poland) · 2025Review
- Rapid Point-of-care Testing to Inform Intrapartum Treatment of Group BOpen forum infectious diseases · 2024Article
- Comparison of qPCR and chromogenic culture methods for rapid detection of group B streptococcus colonization in Vietnamese pregnant women.Practical laboratory medicine · 2024Article
- Development and performance evaluation of a qPCR-based assay for the fully automated detection of group BMicrobiology spectrum · 2024Article
- Establishment and application of a rapid visual diagnostic method for Streptococcus agalactiae based on recombinase polymerase amplification and lateral flow strips.Scientific reports · 2024Article
- Do NAAT-Based Methods Increase the Diagnostic Sensitivity ofDiagnostics (Basel, Switzerland) · 2023Article
- Updates on Group BMicroorganisms · 2022Review
- Label-free single-particle imaging approach for ultra-rapid detection of pathogenic bacteria in clinical samples.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An Application of Real-Time PCR and CDC Protocol May Significantly Reduce the Incidence ofPathogens (Basel, Switzerland) · 2022Article
- Evaluation of Xpert GBS assay and Xpert GBS LB assay for detection of Streptococcus agalactiae.Annals of clinical microbiology and antimicrobials · 2021Article
- Relationship between vaginal group B streptococcus colonization in the early stage of pregnancy and preterm birth: a retrospective cohort study.BMC pregnancy and childbirth · 2021Article
- Visual multiple cross displacement amplification for the rapid identification of S. agalactiae immediately from vaginal and rectal swabs.AMB Express · 2021Article
- Development of a droplet digital PCR method for detection of Streptococcus agalactiae.BMC microbiology · 2020Article
- Highly Sensitive and Rapid Identification ofFrontiers in microbiology · 2020Article
- Streptococcus Agalactiae Carriage, Serotype Distribution and Associated Antibiogram among Pregnant and Non-pregnant Women in Jos City, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGroup B Streptococcus (GBS) is one of the most important causative agents of neonatal sepsis. As administration of prophylactic antibiotics during labor can prevent GBS infection, routine screening for this bacterium in prenatal care before the onset of labor is recommended. However, many women present in labor without having undergone such testing during antenatal care, and the turnaround time of detection methods is insufficient for results to be obtained before delivery.
methodsVaginal and anorectal specimens were collected from 270 pregnant women. Each sample was tested by Xpert GBS, qPCR, and culture for GBS detection.
resultsThe overall prevalence of maternal GBS colonization was 30.7% according to Xpert GBS, 51.1% according to qPCR, and 14.3% according to cultures. Considering the qPCR method as the reference, the Xpert GBS had a sensitivity of 53% and specificity of 93%. Positive Xpert GBS results were correlated to marital status (married or cohabitating) and with prematurity as a cause of neonatal hospitalization. Positive cultures were related with ischemic-hypoxic encephalopathy requiring therapeutic hypothermia.
conclusionsCombined enrichment/qPCR and the Xpert GBS rapid test found a high prevalence of GBS colonization. The Xpert GBS technique gives faster results and could be useful for evaluating mothers who present without antenatal GBS screening results and are at risk of preterm labor, thus allowing institution of prophylactic antibiotic therapy.
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