Evidence map›Paper›PMID 31888571›Full record

ArticleBMC public health2019

The impact of data quality and source data verification on epidemiologic inference: a practical application using HIV observational data.

Mark J Giganti, Bryan E Shepherd, Yanink Caro-Vega, Paula M Luz, Peter F Rebeiro, Marcelle Maia, Gaetane Julmiste, Claudia Cortes, Catherine C McGowan, Stephany N Duda

Abstract read
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  7. Optimal multiwave validation of secondary use data with outcome and exposure misclassification.The Canadian journal of statistics = Revue canadienne de statistique · 2024
    Article
  8. Article
  9. Source Data Verification (SDV) quality in clinical research: A scoping review.Journal of clinical and translational science · 2024
    Article
  10. Article
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mark J GigantiVanderbilt University School of Medicine, Nashville, TN, USA. mark.giganti@vanderbilt.edu.ORCID http://orcid.org/0000-0003-2255-9756
Bryan E ShepherdVanderbilt University School of Medicine, Nashville, TN, USA.
Yanink Caro-VegaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Paula M LuzInstituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Peter F RebeiroVanderbilt University School of Medicine, Nashville, TN, USA.
Marcelle MaiaUniversidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gaetane JulmisteLes Centres GHESKIO, Port-au-Prince, Haiti.
Claudia CortesFundación Arriarán, University of Chile School of Medicine, Santiago, Chile.
Catherine C McGowanVanderbilt University School of Medicine, Nashville, TN, USA.
Stephany N DudaVanderbilt University School of Medicine, Nashville, TN, USA.

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
Statistical methods and designs for correlated outcome and covariate errors in studies of HIV/AIDSR37AI131771 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pamela A Shaw, Bryan Earl Shepherd · 2023 to 2026
$3.4M
Statistical methods for correlated outcome and covariate errors in studies of HIV/AIDSR01AI131771 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHAW, PAMELA A, SHEPHERD, BRYAN EARL · 2018 to 2022
$3.0M
The HIV Care Continuum and Health Policy: Changes through Context and GeographyK01AI131895 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI REBEIRO, PETER F · 2017 to 2021
$623k
NIAID NIH HHS K01 AI131895NIAID NIH HHS R01 AI131771NIAID NIH HHS R37 AI131771NIAID NIH HHS U01 AI069923NIH HHS R01AI131771NIH HHS U01AI069923
6 · The paper itself

Abstract

backgroundData audits are often evaluated soon after completion, even though the identification of systematic issues may lead to additional data quality improvements in the future. In this study, we assess the impact of the entire data audit process on subsequent statistical analyses.

methodsWe conducted on-site audits of datasets from nine international HIV care sites. Error rates were quantified for key demographic and clinical variables among a subset of records randomly selected for auditing. Based on audit results, some sites were tasked with targeted validation of high-error-rate variables resulting in a post-audit dataset. We estimated the times from antiretroviral therapy initiation until death and first AIDS-defining event using the pre-audit data, the audit data, and the post-audit data.

resultsThe overall discrepancy rate between pre-audit and audit data (n = 250) across all audited variables was 17.1%. The estimated probability of mortality and an AIDS-defining event over time was higher in the audited data relative to the pre-audit data. Among patients represented in both the post-audit and pre-audit cohorts (n = 18,999), AIDS and mortality estimates also were higher in the post-audit data.

conclusionThough some changes may have occurred independently, our findings suggest that improved data quality following the audit may impact epidemiological inferences.

Indexed as

Data AccuracyEpidemiologic Research DesignHIV InfectionsHumansObservationData auditData qualityHIVLatin AmericaObservational dataSource data verification

Identifiers

PMID31888571
PMCPMC6937856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.