Evidence map›Paper›PMID 31888514›Full record

ArticleBMC geriatrics2019

Bacteriuria and vitamin D deficiency: a cross sectional study of 385 nursing home residents.

Rebeka Arnljots, Egill Snaebjörnsson Arnljots, Jörgen Thorn, Marie Elm, Michael Moore, Pär-Daniel Sundvall

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Rebeka ArnljotsResearch and Development Primary Health Care, Region Västra Götaland, Research and Development Centre Södra Älvsborg Sweden, Sven Eriksonsplatsen 4, SE-503 38, Borås, Sweden. rebeka.arnljots@vgregion.se.
Egill Snaebjörnsson ArnljotsResearch and Development Primary Health Care, Region Västra Götaland, Research and Development Centre Södra Älvsborg Sweden, Sven Eriksonsplatsen 4, SE-503 38, Borås, Sweden.
Jörgen ThornDepartment of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Box 454, SE-405 30, Gothenburg, Sweden.
Marie ElmHealth Care Unit Borås Municipality, Ramnåsgatan 1, SE-501 80, Borås, Sweden.
Michael MooreAcademic Unit of Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton, SO16 5ST, UK.
Pär-Daniel SundvallResearch and Development Primary Health Care, Region Västra Götaland, Research and Development Centre Södra Älvsborg Sweden, Sven Eriksonsplatsen 4, SE-503 38, Borås, Sweden.
Kista Photonics Research Center · SERegion Västra Götaland · SESandvik (Sweden) · SEUniversity of Borås · SEUniversity of Gothenburg · SEUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUp to half of elderly people at nursing homes have asymptomatic bacteriuria, and concentrations of 25-hydroxyvitamin D (25OHD) are generally low. Vitamin D is a modulator of the immune system and involved in protection of the epithelium in the urinary tract as well. The objective was to determine a possible association between bacteriuria and vitamin D deficiency among elderly people at nursing homes.

methodsCross-sectional study: Voided urine specimens and blood samples for cultivation and analysis of 25OHD were collected from elderly people at nursing homes in Sweden. Exclusion criteria were: urinary catheter, ongoing antibiotic treatment, incontinence or dementia too severe to provide a voided urine specimen or leave a blood sample, unwillingness to participate or terminal illness. Urine cultures and serum 25OHD concentrations were outcome measures and the association of bacteriuria with vitamin D deficiency was determined by logistic regression.

resultsTwenty-two nursing homes participated and 385 of 901elderly people provided voided urine specimens and blood samples. The mean age was 87 (SD 6.7), 69% women, 19% received vitamin D supplement, 13% had diabetes mellitus, and 54% were diagnosed with dementia. There was significant growth of potentially pathogenic bacteria in 32% (123/385) of voided urine specimens. Escherichia coli were present in 83% of positive urine cultures. The mean concentration of 25OHD in serum was 35 nmol/L (SD 21). Thirty-seven per cent (143/385) had 25OHD < 25 nmol/L, and 3.1% (12/385) 25OHD < 12.5 nmol/L. No association between bacteriuria and 25OHD < 25 nmol/L, OR 1.4 (0.86-2.3; p = 0.18) adjusted for age, gender, diabetes mellitus and dementia was found. However, if using 25OHD < 12.5 nmol/L as a cut-off for vitamin D deficiency the adjusted odds-ratio was 4.4 (1.1-17; p = 0.031).

conclusionsBacteriuria and vitamin D deficiency was common. No association between bacteriuria and 25OHD < 25 nmol/L was found. If using 25OHD < 12.5 nmol/L as cut-off for vitamin D deficiency there was an association. However, this has to be interpreted with caution as causality cannot be evaluated as well as only few residents had 25OHD < 12.5 nmol/L.

Indexed as

AgedAged, 80 and overBacteriuriaCross-Sectional StudiesDementiaDietary SupplementsFemaleHumansMaleNursing HomesSwedenUrinalysisVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin DBacteriuriaFrail elderlyHomes for the agedNursing homesUrinary tract infectionsVitamin D

Identifiers

PMID31888514
PMCPMC6937784
OpenAlexW2998008396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.