Evidence map›Paper›PMID 31888509›Full record

SynthesisBMC anesthesiology2019

Efficacy and safety of prophylactic use of ketamine for prevention of postanesthetic shivering: a systematic review and meta analysis.

Yang Zhou, Abdul Mannan, Yuan Han, He Liu, Hui-Lian Guan, Xing Gao, Ming-Sheng Dai, Jun-Li Cao

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  15. [Inhalational anesthetics].Der Anaesthesist · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yang ZhouDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Abdul MannanDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Yuan HanDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
He LiuDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Hui-Lian GuanDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Xing GaoDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Ming-Sheng DaiDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China.
Jun-Li CaoDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 2210002, Jiangsu, China. junlicao0310@163.com.ORCID 0000-0003-1868-9603
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostanesthetic shivering is a common complication of anesthesia, which accounts for much discomfort in postoperative patients and may increase postoperative complications in high-risk patients. Due to the lack of high-quality evidence, it is difficult to draw a conclusion about optimal anti-shivering medication. The main purpose of this meta-analysis was to analyze and evaluate the efficacy and safety of prophylactic use of ketamine for preventing postanesthetic shivering.

methodsWe searched the following databases: Medline, Embase, and the Cochrane Central Register of Controlled Trails for randomized controlled trials. The primary outcome observed was the difference of the incidence rate of postanesthetic shivering between ketamine group and placebo group. The secondary outcomes were the sedation score and incidence of the side effects caused by ketamine and any other drugs utilized in the studies.

resultsIn this meta-analysis, we analyzed a total of 16 trials including 1485 patients. Ketamine reduced the incidence rate of postanesthetic shivering compared to a placebo (odds ratio [OR]: 0.13, 95% confidence interval [CI]: 0.06 to 0.26, P<0.01). Regarding side effects, there was no evident variability of the incidence of nausea and vomiting. Usage of ketamine was associated with a lower rate of hypotension and bradycardia when compared to a placebo. Hallucinations were more frequently observed in patients who received higher doses of ketamine. No significant difference was found in the incidence of postanesthetic shivering with ketamine versus other pharmacological interventions.

conclusionsKetamine can prevent postanesthetic shivering without severe side effects. However, ketamine shows no advantage over other anti-shivering drugs.

Indexed as

AnesthesiaAnesthetics, DissociativeHumansIncidenceKetaminePostoperative ComplicationsRandomized Controlled Trials as TopicShiveringAnesthetics, DissociativeKetamineAnti-shiveringKetaminePostanesthetic shivering

Identifiers

PMID31888509
PMCPMC6937868
OpenAlexW2998454773

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.