ArticleBMC microbiology2019
Composite genome sequence of Bacillus clausii, a probiotic commercially available as Enterogermina
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Protective effects of Bacillus clausii in cyclophosphamide-induced immunosuppression and intestinal mucositis in rats: histopathological and inflammatory evaluation.Molecular biology reports · 2026Article
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- Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing andGut microbes reports · 2026Article
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- Evaluating the Compositional Quality of Probiotics Containing Bacillus clausii in India.Advances in therapy · 2025Article
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- Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine.BMC microbiology · 2025Article
- The Resistance Abilities of SomeFood science & nutrition · 2025Article
- Randomized Clinical Trials Demonstrate the Safety Assessment ofMicroorganisms · 2024Article
- Comparative Genomics and In Vitro Experiments Provide Insight into the Adaptation and Probiotic Properties ofMicroorganisms · 2024Article
- Whole genome sequence analysis of Bacillus amyloliquefaciens strain S2.5 as a potential probiotic for feed supplement in livestock production.Journal, genetic engineering & biotechnology · 2024Article
- Strain-Dependent Adhesion Variations ofMicroorganisms · 2024Article
- The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization.Microorganisms · 2024Article
- Genetic and Phenotypic Characterization ofMicroorganisms · 2024Article
- In Silico Safety Assessment ofInternational journal of molecular sciences · 2024Article
- Biorefinery-inspired, two-step valorization strategy to manage plant-based recalcitrant organic waste, involving solvent extraction, and fermentation withFrontiers in microbiology · 2024Article
- Characterization and in-depth genome analysis of a halotolerant probiotic bacterium Paenibacillus sp. S-12, a multifarious bacterium isolated from Rauvolfia serpentina.BMC microbiology · 2023Article
- Genetic and phenotypic assessments for the safety of probiotic3 Biotech · 2023Article
- Lysinibacillus capsici 38,328 isolated from agricultural soils as a promising probiotic candidate for intestinal health.Archives of microbiology · 2023Article
- Immunomodulatory and Antioxidant Properties of a Novel Potential ProbioticMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome of the spore-forming strains of Bacillus probiotics are marketed commercially as they survive harsh gastrointestinal conditions and bestow health benefits to the host.
resultsWe report the composite genome of Bacillus clausii ENTPro from a commercially available probiotic Enterogermina® and compare it with the genomes of other Bacillus probiotics. We find that the members of B. clausii species harbor high heterogeneity at the species as well as genus level. The genes conferring resistance to chloramphenicol, streptomycin, rifampicin, and tetracycline in the B. clausii ENTPro strain could be identified. The genes coding for the bacteriocin gallidermin, which prevents biofilm formation in the pathogens Staphylococcus aureus and S. epidermidis, were also identified. KEGG Pathway analysis suggested that the folate biosynthesis pathway, which depicts one of the important roles of probiotics in the host, is conserved completely in B. subtilis and minimally in B. clausii and other probiotics.
conclusionsWe identified various antibiotic resistance, bacteriocins, stress-related, and adhesion-related domains, and industrially-relevant pathways, in the genomes of these probiotic bacteria that are likely to help them survive in the harsh gastrointestinal tract, facilitating adhesion to host epithelial cells, persistence during antibiotic treatment and combating bacterial infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.