Trial reportClinical pediatrics2020
Laboratory Findings After Urinary Tract Infection and Antimicrobial Prophylaxis in Children With Vesicoureteral Reflux.
Milan Dattaram Nadkarni, Tej K Mattoo, Lisa Gravens-Mueller, Myra A Carpenter, Anastasia Ivanova, Marva Moxey-Mims, Saul P Greenfield, Ranjiv Mathews
Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraphTrial report in Clinical pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 10 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors at 6 institutions in 1 country.
Tej K MattooChildren's Hospital of Michigan, Detroit, MI, USA.
Lisa Gravens-MuellerUniversity of North Carolina, Chapel Hill, NC, USA.
Myra A CarpenterUniversity of North Carolina, Chapel Hill, NC, USA.
Anastasia IvanovaUniversity of North Carolina, Chapel Hill, NC, USA.
Marva Moxey-MimsChildren's National Medical Center, Washington, DC, USA.
Saul P GreenfieldState University of New York at Buffalo, NY, USA.
Ranjiv MathewsSouthern Illinois University, Springfield, IL, USA.
University of North Carolina at Chapel Hill · USChildren's Hospital of Michigan · USChildren's National · USSouthern Illinois University School of Medicine · USUniversity at Buffalo, State University of New York · USWake Forest University · US
Funding
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MRandomized Intervention for Vesicoureteral Reflux (RIVUR)U01DK074059 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARPENTER, MYRA A. · 2005 to 2012
$11.3MPOET Study: Clinical Trial of Girls with RefluxU01DK074063 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GREENFIELD, SAUL PHILIP · 2005 to 2012
$5.0MRIVUR - Randomized Intervention for Children with Vesicoureteral RefluxU01DK074053 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOBERMAN, ALEJANDRO · 2005 to 2012
$4.3MRIVUR StudyU01DK074062 · NIDDK · WAYNE STATE UNIVERSITY · PI MATTOO, TEJ K · 2005 to 2012
$4.0MRandomized Intervention for VesicolUreteral Reflux (RIVUR) StudyU01DK074064 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KEREN, RON · 2005 to 2012
$2.8MRandomized Intervention for Vesico-Ureteral Reflux (RIVUR) TrialU01DK074082 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WANG, MING-HSIEN · 2005 to 2012
$2.5MNCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIDDK NIH HHS U01 DK074053NIDDK NIH HHS U01 DK074059NIDDK NIH HHS U01 DK074062NIDDK NIH HHS U01 DK074063NIDDK NIH HHS U01 DK074064NIDDK NIH HHS U01 DK074082
6 · The paper itselfAbstract
It is a common practice to monitor blood tests in patients receiving long-term trimethoprim-sulfamethoxazole (TMP-SMZ) prophylaxis for recurrent urinary tract infections. This multicenter, randomized, placebo-controlled trial enrolled 607 children aged 2 to 71 months with vesicoureteral reflux diagnosed after symptomatic urinary tract infection. Study participants received TMP-SMZ (n = 302) or placebo (n = 305) and were followed for 2 years. Serum electrolytes (n ≥ 370), creatinine (n = 310), and complete blood counts (n ≥ 206) were measured at study entry and at the 24-month study conclusion. We found no significant electrolyte, renal, or hematologic abnormalities when comparing the treatment and placebo groups. We observed changes in several laboratory parameters in both treatment and placebo groups as would normally be expected with physiologic maturation. Changes were within the normal range for age. Long-term use of TMP-SMX had no treatment effect on complete blood count, serum electrolytes, or creatinine. Our findings do not support routine monitoring of these laboratory tests in children receiving long-term TMP-SMZ prophylaxis.
Indexed as
Anti-Infective Agents, UrinaryBiomarkersChildChild, PreschoolDrug MonitoringFemaleFollow-Up StudiesHumansInfantMaleProspective StudiesRecurrenceSecondary PreventionTreatment OutcomeTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsAnti-Infective Agents, UrinaryBiomarkersTrimethoprim, Sulfamethoxazole Drug Combinationlaboratory monitoringSMZ-TMP prophylaxisurinary tract infectionsvesicoureteral reflux (VUR)
Identifiers
PMID31888378
OpenAlexW2996952807
What OpenQuestion holds
Textmetadata
Read underepoch 390