ArticleThe Korean journal of pain2020
Perioperative duloxetine as part of a multimodal analgesia regime reduces postoperative pain in lumbar canal stenosis surgery: a randomized, triple blind, and placebo-controlled trial.
Article in The Korean journal of pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04294953 (Efficacy of Perioperative Duloxetine as a Part of Multimodal Analgesia in Laparoscopic Colorectal Cancer Surgery), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Perioperative Duloxetine as a Part of Multimodal Analgesia in Laparoscopic Colorectal Cancer Surgery
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Duloxetine for the reduction of opioid use in elective orthopedic surgery: a systematic review and meta-analysis.International journal of clinical pharmacy · 2021Pooled it
- Efficacy of perioperative duloxetine as a part of multimodal analgesia in laparoscopic colorectal cancer surgeries.BMC anesthesiology · 2023Trial
- Efficacy of postoperative analgesia with duloxetine in posthemorrhoidectomy pain: a prospective, randomized, double-blind and placebo-controlled trial.BMC anesthesiology · 2022Trial
- Application of Pain Management After Lumbar Spine Surgery: A Bibliometric Analysis of Randomized Controlled Trials.Pain research & management · 2026Article
- Preoperative spinal education for lumbar spinal stenosis (POSE-LSS): A qualitative analysis of patient experiences.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- Analgesic efficacy and safety of duloxetine premedication in patients undergoing hysterectomy - A systematic review.Indian journal of anaesthesia · 2023Article
- Article
- Pregabalin Versus Duloxetine on Postoperative Analgesic Requirement Following Lower Extremity Trauma Surgeries: A randomised, Clinical Trial.Turkish journal of anaesthesiology and reanimation · 2022Article
- Evaluation of preoperative duloxetine use for postoperative analgesia following laparoscopic cholecystectomy: A randomized controlled trial.Frontiers in pharmacology · 2022Article
- Management of Postoperative Pain in Patients Following Spine Surgery: A Narrative Review.International journal of general medicine · 2022Review
- Topical agents: a thoughtful choice for multimodal analgesia.Korean journal of anesthesiology · 2020Review
- Effect of Single Preoperative Dose of Duloxetine on Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy under Spinal Anesthesia.Anesthesia, essays and researchesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuloxetine is an antidepressant that is also useful in chronic neuropathic and central origin pain. In this study, the role of duloxetine in decreasing acute postoperative pain after lumbar canal stenosis surgery is explored.
methodsIn this single center, triple blinded, and placebo-controlled trial, 96 patients were randomized for statistical analysis. The intervention group received oral duloxetine 30 mg once a day (OD) for 2 days before surgery, 60 mg OD from the day of surgery to the postoperative second day and 30 mg OD for the next 2 days (a total duration of 7 days). A placebo capsule was given in the other group for a similar time and schedule. The same standard perioperative analgesia protocols were followed in both groups.
resultsTotal morphine consumption up to 24 hours was significantly decreased in the duloxetine group (
conclusionsDuloxetine reduces postoperative pain after lumbar canal stenosis surgery with no increase in adverse effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.