ArticleSensors (Basel, Switzerland)2019
Electrochemical Detection of C-Reactive Protein in Human Serum Based on Self-Assembled Monolayer-Modified Interdigitated Wave-Shaped Electrode.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Continuous Lactate Monitoring System Based on Percutaneous Microneedle Array.Sensors (Basel, Switzerland) · 2022Article
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- Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform.Sensors (Basel, Switzerland) · 2021Review
- Electrochemical sensing: A prognostic tool in the fight against COVID-19.Trends in analytical chemistry : TRAC · 2021Review
- Development of an Interdigitated Electrode-Based Disposable Enzyme Sensor Strip for Glycated Albumin Measurement.Molecules (Basel, Switzerland) · 2021Article
- Advancement in biosensors for inflammatory biomarkers of SARS-CoV-2 during 2019-2020.Biosensors & bioelectronics · 2021Review
- Oriented Antibody Covalent Immobilization for Label-Free Impedimetric Detection of C-Reactive ProteinFrontiers in chemistry · 2021Article
- Electrochemical Immunosensor for the Early Detection of Rheumatoid Arthritis Biomarker: Anti-Cyclic Citrullinated Peptide Antibody in Human Serum Based on Avidin-Biotin System.Sensors (Basel, Switzerland) · 2020Article
- Porous Platinum Black-Coated Minimally Invasive Microneedles for Non-Enzymatic Continuous Glucose Monitoring in Interstitial Fluid.Nanomaterials (Basel, Switzerland) · 2020Article
- Interdigitated and Wave-Shaped Electrode-Based Capacitance Sensor for Monitoring Antibiotic Effects.Sensors (Basel, Switzerland) · 2020Article
- A Probeless Capacitive Biosensor for Direct Detection of Amyloid Beta 1-42 in Human Serum Based on an Interdigitated Chain-Shaped Electrode.Micromachines · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
An electrochemical capacitance immunosensor based on an interdigitated wave-shaped micro electrode array (IDWµE) for direct and label-free detection of C-reactive protein (CRP) was reported. A self-assembled monolayer (SAM) of dithiobis (succinimidyl propionate) (DTSP) was used to modify the electrode array for antibody immobilization. The SAM functionalized electrode array was characterized morphologically by atomic force microscopy (AFM) and energy dispersive X-ray spectroscopy (EDX). The nature of gold-sulfur interactions on SAM-treated electrode array was probed by X-ray photoelectron spectroscopy (XPS). The covalent linking of anti-CRP-antibodies onto the SAM modified electrode array was characterized morphologically through AFM, and electrochemically through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The application of phosphate-buffered saline (PBS) and human serum (HS) samples containing different concentrations of CRP in the electrode array caused changes in the electrode interfacial capacitance upon CRP binding. CRP concentrations in PBS and HS were determined quantitatively by measuring the change in capacitance (ΔC) through EIS. The electrode immobilized with anti-CRP-antibodies showed an increase in ΔC with the addition of CRP concentrations over a range of 0.01-10,000 ng mL
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