Evidence map›Paper›PMID 31888227›Full record

ReviewJournal of fungi (Basel, Switzerland)2019

Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection.

Jeffrey D Jenks, Stephen A Rawlings, Carol Garcia-Vidal, Philipp Koehler, Toine Mercier, Juergen Prattes, Cornelia Lass-Flörl, M Teresa Martin-Gomez, Dieter Buchheidt, Livio Pagano and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Studies in mycology · 2021
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 9 countries.

Jeffrey D JenksDepartment of Medicine, University of California San Diego, San Diego, CA 92103, USA.ORCID 0000-0001-6632-9587
Stephen A RawlingsClinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3637-1447
Carol Garcia-VidalInfectious Diseases Department, Hospital Clinic-IDIBAPS, 08036 Barcelona, Spain.
Philipp KoehlerUniversity of Cologne, Faculty of Medicine, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), University Hospital of Cologne, 50931 Cologne, Germany.ORCID 0000-0002-7386-7495
Toine MercierDepartment of Hematology, University Hospitals Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-1517-6426
Juergen PrattesSection of Infectious Diseases and Tropical Medicine and Division of Pulmonology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5751-9311
Cornelia Lass-FlörlDepartment of Microbiology and Hygiene, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2946-7785
M Teresa Martin-GomezDepartment of Microbiology, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.ORCID 0000-0001-8119-8749
Dieter BuchheidtDepartment of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-4425-6134
Livio PaganoDepartment of Hematology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-8287-928X
Jean-Pierre GangneuxCHU de Rennes, Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail)-UMR_S, 1085 Rennes, France.ORCID 0000-0002-4974-5607
Frank L van de VeerdonkDepartment of Internal Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0001-8935-8030
Martin HoeniglClinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1653-2824
Medical University of Graz · ATRadboud University Nijmegen · NLUniversity of California San Diego · USHeidelberg University · DEHospital Clínic de Barcelona · ESInnsbruck Medical University · ATInserm · FRKU Leuven · BEUniversità Cattolica del Sacro Cuore · ITUniversity of Cologne · DEUniversity of Minho · PTVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections.

Indexed as

Aspergillusimmune responseinterleukin 10interleukin 6interleukin 8invasive aspergillosisinvasive mold infectionsmold-reactive T-cellsMucormycosisprognosis

Identifiers

PMID31888227
PMCPMC6958498
OpenAlexW2996076171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.