Evidence map›Paper›PMID 31888099›Full record

ArticleMolecules (Basel, Switzerland)2019

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties.

De-Yang Sun, Chen Cheng, Katrin Moschke, Jian Huang, Wei-Shuo Fang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

De-Yang SunState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China.
Chen ChengCollege of Life Science, Wuhan University, Wuhan, Hubei 430072, China.
Katrin MoschkeGerman Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy), Technical University of Munich, Feodor-Lynen-Strasse 17, 81377 Munich, Germany.
Jian HuangCollege of Life Science, Wuhan University, Wuhan, Hubei 430072, China.
Wei-Shuo FangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China.

Funding

National Natural Science Foundation of China 31371331National Natural Science Foundation of China 81273406
6 · The paper itself

Abstract

BACE1 inhibitory conjugates derived from two natural products, luteolin (

Indexed as

Amyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCinnamatesEnzyme InhibitorsHumansLuteolinMolecular StructureProtein BindingStructure-Activity RelationshipAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanCinnamatescinnamic acidEnzyme InhibitorsLuteolinBACE1 inhibitorbeta-secretasecinnamic acidflavonoidluteolin

Identifiers

PMID31888099
PMCPMC6982702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.