ArticleThrombosis and haemostasis2020
Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis.
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Article in Thrombosis and haemostasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Loss of factor XIII decreases immune cell infiltration and enhances vessel wall endothelialization after venous thrombosis.Blood advances · 2026Article
- Monocyte depletion reduces late experimental post-thrombotic fibrotic injury in a stasis mouse model.Thrombosis research · 2026Article
- Immune drivers of venous thrombosis: orchestrating initiation, formation, and resolution within the hypoxic microenvironment.Frontiers in immunology · 2026Review
- Advanced Research in the Pathophysiology of Venous Thromboembolism-Acute Pulmonary Embolism.Biomedicines · 2025Review
- Causal Relationship Between Immune Cells and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.Vascular health and risk management · 2025Article
- Regulation of macrophage fibrinolysis during venous thrombus resolution.Thrombosis research · 2024Article
- Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- NanoSHP099-Targeted SHP2 Inhibition Boosts Ly6CAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Monocyte/macrophage-mediated venous thrombus resolution.Frontiers in immunology · 2024Review
- Monocyte recruitment in venous pulmonary embolism at time of cancer diagnosis in upper gastrointestinal cancer patients.Journal of thrombosis and thrombolysis · 2024Article
- The significance of CD16+ monocytes in the occurrence and development of chronic thromboembolic pulmonary hypertension: insights from single-cell RNA sequencing.Frontiers in immunology · 2024Article
- Immune cell-mediated venous thrombus resolution.Research and practice in thrombosis and haemostasis · 2023Review
- Sympathetic Nerves Coordinate Corneal Epithelial Wound Healing by Controlling the Mobilization of Ly6Chi Monocytes From the Spleen to the Injured Cornea.Investigative ophthalmology & visual science · 2023Article
- Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.Nature communications · 2023Article
- Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions.Scientific reports · 2023Article
- The role of monocytes in thrombotic diseases: a review.Frontiers in cardiovascular medicine · 2023Review
- Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy.Frontiers in immunology · 2023Review
- Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis.Journal of thrombosis and haemostasis : JTH · 2022Article
- Endothelial Cell Phenotype, a Major Determinant of Venous Thrombo-Inflammation.Frontiers in cardiovascular medicine · 2022Review
- Modulation of interleukin-6 and its effect on late vein wall injury in a stasis mouse model of deep vein thrombosis.JVS-vascular science · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Andrew Scott KimballDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Andrea Tara ObiDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-7613-2366
Catherine E LukeDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Abigail R DowlingDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Qing CaiDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Reheman AdiliDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States.
Hannah JankowskiDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Matthew SchallerDivision of Pulmonary Critical Care Medicine, University of Florida, Gainesville, Florida, United States.
Michael HolinstadtDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States.
Farouc A JafferDepartment of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States.
Steven L KunkelDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, United States.
Katherine A GallagherDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
Peter K HenkeDepartment of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, Michigan, United States.
University of Michigan · USMassachusetts General Hospital · USUniversity of Florida · US
Funding
The Monocyte/Macrophage Role in Experimental Deep Vein Thrombosis Resolution and Vein Wall InjuryR01HL144550 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2020 to 2023
$2.2MVascular Surgery: Research Training in Vascular BiologyT32HL076123 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K, WAKEFIELD, THOMAS WILLIAM · 2004 to 2019
$1.9MThe Role of IL-6 in Experimental Post Thrombotic SyndromeR01HL132988 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2016 to 2019
$1.9MNHLBI NIH HHS R01 HL132988NHLBI NIH HHS R01 HL144550NHLBI NIH HHS T32 HL076123
Abstract
Venous thrombosis (VT) resolution is a complex process, resembling sterile wound healing. Infiltrating blood-derived monocyte/macrophages (Mo/MΦs) are essential for the regulation of inflammation in tissue repair. These cells differentiate into inflammatory (CD11b
Indexed as
Adoptive TransferAnimalsAntigens, LyCD11 AntigensCell SeparationDiphtheria ToxinEnzyme-Linked Immunosorbent AssayInflammationLeukocytesLysosomesMacrophagesMiceMice, Inbred C57BLMonocytesNeutrophilsPhenotypeAntigens, LyCD11 AntigensDiphtheria ToxinLy-6C antigen, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.