Evidence map›Paper›PMID 31887275›Full record

ArticleBiochimica et biophysica acta. Biomembranes2020

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

Sarah J Routledge, John Simms, Ashley Clark, Ho Yan Yeung, Mark J Wigglesworth, Ian M Dickerson, Philip Kitchen, Graham Ladds, David R Poyner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Inhibition of CGRP signaling impairs fracture healing in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sarah J RoutledgeSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. Electronic address: s.routledge@aston.ac.uk.
John SimmsSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. Electronic address: j.simms@aston.ac.uk.
Ashley ClarkDepartment of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK. Electronic address: ajc302@cam.ac.uk.
Ho Yan YeungDepartment of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK. Electronic address: hyy24@cam.ac.uk.
Mark J WigglesworthHit Discovery, Discovery Sciences, R&D, BioPharmaceuticals, AstraZeneca, Macclesfield, UK. Electronic address: Mark.Wigglesworth@astrazeneca.com.
Ian M DickersonDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: Ian_Dickerson@urmc.rochester.edu.
Philip KitchenSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. Electronic address: p.kitchen@aston.ac.uk.
Graham LaddsDepartment of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK. Electronic address: grl30@aston.ac.uk.
David R PoynerSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. Electronic address: d.r.poyner@aston.ac.uk.
Aston University · GBUniversity of Cambridge · GBAstraZeneca (United Kingdom) · GBUniversity of Rochester Medical Center · US

Funding

Biotechnology and Biological Sciences Research Council BB/M000176/2
6 · The paper itself

Abstract

Receptor component protein (RCP) is a 148 amino acid intracellular peripheral membrane protein, previously identified as promoting the coupling of CGRP to cAMP production at the CGRP receptor, a heterodimer of calcitonin receptor like-receptor (CLR), a family B G protein-coupled receptor (GPCR) and receptor activity modifying protein 1 (RAMP1). We extend these observations to show that it selectively enhances CGRP receptor coupling to Gs but not Gq or pERK activation. At other family B GPCRs, it enhances cAMP production at the calcitonin, corticotrophin releasing factor type 1a and glucagon-like peptide type 2 receptors with their cognate ligands but not at the adrenomedullin type 1 (AM

Indexed as

Adaptor Proteins, Signal TransducingAdrenomedullinAnimalsCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCyclic AMPHEK293 CellsHumansLigandsMembrane ProteinsPeptide HormonesReceptor Activity-Modifying Protein 1Receptors, G-Protein-CoupledSignal TransductionAdaptor Proteins, Signal TransducingAdrenomedullinCALCA protein, humanCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCyclic AMPLigandsMembrane ProteinsPeptide HormonesRAB11FIP1 protein, humanRAMP1 protein, humanReceptor Activity-Modifying Protein 1Receptors, G-Protein-CoupledAccessory proteinAdrenomedullinAllosteric modulatorCGRPGPCR signallingG protein coupling

Identifiers

PMID31887275
PMCPMC6977087
OpenAlexW2997828768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.