Evidence map›Paper›PMID 31887168›Full record

Trial reportPloS one2019

Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function-A follow-up of the CONTEXT study.

Marie B Nielsen, Nicoline V Krogstrup, Mihai Oltean, Gertrude J Nieuwenhuijs-Moeke, Frank J M F Dor, Henrik Birn, Bente Jespersen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01395719 (Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01395719 naunknown statusnot on this map

Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function

TypeinterventionalSponsorUniversity of AarhusRan2011 to 2016Enrolled220ConditionsKidney Transplantation, Delayed Graft Function, Acute Kidney Injury, Glomerular Filtration RateArmsRemote ischemic conditioning
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Marie B NielsenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3587-6638
Nicoline V KrogstrupDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Mihai OlteanThe Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
Gertrude J Nieuwenhuijs-MoekeDepartment of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-9874-2632
Frank J M F DorDivision of HPB & Transplant Surgery, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Henrik BirnDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Bente JespersenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Aarhus University · DKHammersmith Hospital · GBHerlev Hospital · DKSahlgrenska University Hospital · SEUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschaemia-reperfusion injury in kidney transplantation leads to delayed graft function (DGF), which is associated with reduced long term graft function. Remote ischaemic conditioning (RIC) improved early kidney graft function in a porcine model of donation after brain death and was associated with improved long-term cardiac outcome after myocardial ischaemia. This randomised, double-blinded trial evaluated the effect of RIC on kidney graft outcome in the first year, and examined the predictive value of a new measure of initial kidney graft function, i.e. the estimated time to a 50% reduction in plasma creatinine post-transplantation (tCr50).

methodsA total of 225 patients undergoing deceased donor kidney transplantation were randomised to RIC or a sham procedure performed prior to kidney reperfusion. Up to four repetitive cycles of five minutes of leg ischaemia and five minutes of reperfusion were given. GFR, plasma creatinine, cystatin C and neutrophil gelatinase associated lipocalin (NGAL) were measured at three and twelve months and estimated GFR was calculated using four different equations. Other secondary outcomes were identified from patient files.

resultsRIC did not affect GFR or other outcomes when compared to the sham procedure at three or twelve months. tCr50 correlated with one year graft function (p<0.0001 for both mGFR and eGFR estimates). In contrast, DGF i.e. "need of dialysis the first week" did not correlate significantly with one year GFR.

conclusionRIC during deceased donor kidney transplantation did not improve one year outcome. However, tCr50 may be a relevant marker for studies aiming to improve graft onset.

trial registrationwww.ClinicalTrials.gov Identifier: NCT01395719.

Indexed as

Delayed Graft FunctionKidney TransplantationAgedAnimalsBiomarkersCreatinineCystatin CFemaleFollow-Up StudiesGraft SurvivalHumansIschemic PreconditioningLipocalin-2MaleMiddle AgedReperfusion InjuryBiomarkersCreatinineCST3 protein, humanCystatin CLipocalin-2

Identifiers

PMID31887168
PMCPMC6936785
OpenAlexW2998610808

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.