ArticlePloS one2019
Potentially inappropriate medication in older participants of the Berlin Aging Study II (BASE-II) - Sex differences and associations with morbidity and medication use.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Long-term intake of statins or renin-angiotensin system inhibitors: associations with sarcopenia-related parameters in older people.GeroScience · 2026Article
- Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe.Annals of medicine · 2025Article
- Geographic and socioeconomic differences in potentially inappropriate medication among older adults - applying a simplified analysis of individual heterogeneity and discriminatory accuracy (AIHDA) for basic comparisons of healthcare quality.BMC health services research · 2025Article
- Assessment of potentially inappropriate medication use among geriatric outpatients in the Slovak Republic.BMC geriatrics · 2023Article
- High burden of polypharmacy and comorbidity in persons with psoriatic arthritis: an analysis of claims data, stratified by age and sex.RMD open · 2023Article
- Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study.International journal of environmental research and public health · 2023Article
- The Sex-Specific Impact of the FORTA (Fit-fOR-The-Aged) List on Medication Quality and Clinical Endpoints in Older Hospitalized Patients: Secondary Analysis of a Randomized Controlled Trial.Drugs - real world outcomes · 2022Article
- Linking Brain Age Gap to Mental and Physical Health in the Berlin Aging Study II.Frontiers in aging neuroscience · 2022Article
- Trends and patterns in EU(7)-PIM prescribing to elderly patients in Germany.European journal of clinical pharmacology · 2021Observational
- Observational
- Are there sex differences in potentially inappropriate prescribing in adults with multimorbidity?Journal of the American Geriatrics Society · 2021Article
- Epidemiology and associated factors of polypharmacy in older patients in primary care: a northern Italian cross-sectional study.BMC geriatrics · 2021Article
- Potentially Inappropriate Drug Duplication in a Cohort of Older Adults with Dementia.Current therapeutic research, clinical and experimental · 2021Article
- Potentially Inappropriate Prescriptions to Older Patients in Emergency Departments in South Korea: A Retrospective Study.Therapeutics and clinical risk management · 2021Article
- Medication Evaluation in Portuguese Elderly Patients According to Beers, STOPP/START Criteria and EU(7)-PIM List - An Exploratory Study.Patient preference and adherence · 2020Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionMultimorbidity in advanced age and the need for drug treatment may lead to polypharmacy, while pharmacokinetic and pharmacodynamic changes may increase the risk of adverse drug events (ADEs).
objectiveThe aim of this study was to determine the proportion of subjects using potentially inappropriate medication (PIM) in a cohort of older and predominantly healthy adults in relation to polypharmacy and morbidity.
methodsCross-sectional data were available from 1,382 study participants (median age 69 years, IQR 67-71, 51.3% females) of the Berlin Aging Study II (BASE-II). PIM was classified according to the EU(7)-PIM and German PRISCUS (representing a subset of the former) list. Polypharmacy was defined as the concomitant use of at least five drugs. A morbidity index (MI) largely based on the Charlson Index was applied to evaluate the morbidity burden.
resultsOverall, 24.1% of the participants were affected by polypharmacy. On average, men used 2 (IQR 1-4) and women 3 drugs (IQR 1-5). According to PRISCUS and EU(7)-PIM, 5.9% and 22.6% of participants received at least one PIM, while use was significantly more prevalent in females (25.5%) compared to males (19.6%) considering EU(7)-PIM (p = 0.01). In addition, morbidity in males receiving PIM according to EU(7)-PIM was higher (median MI 1, IQR 1-3) compared to males without PIM use (median MI 1, IQR 0-2, p<0.001).
conclusionPIM use occurred more frequently in women than in men, while it was associated with higher morbidity in males. As expected, EU(7)-PIM identifies more subjects as PIM users than the PRISCUS list but further studies are needed to investigate the differential impact of both lists on ADEs and outcome. KEY POINTS: We found PIM use to be associated with a higher number of regular medications and with increased morbidity. Additionally, we detected a higher prevalence of PIM use in females compared to males, suggesting that women and people needing intensive drug treatment are patient groups, who are particularly affected by PIM use.
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