ArticlePloS one2019
Optical coherence tomography angiography reveals progressive worsening of retinal vascular geometry in diabetic retinopathy and improved geometry after panretinal photocoagulation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Nitric oxide as a mechanistic link between metabolic dysfunction and cognitive decline in type 2 diabetes.Biochemical Society transactions · 2026Review
- Using OCT Angiography to Predict Diabetic Retinopathy Progression and Vision Decline in a Multiethnic Cohort.Ophthalmology science · 2026Article
- Choriocapillaris perfusion assessed using optical coherence tomography angiography depends on eye color and projection artifact removal.International ophthalmology · 2025Article
- Deep learning for retinal non-perfusion and foveal avascular zone analysis in wide-field OCTA in diabetic retinopathy.Scientific reports · 2025Article
- Diabetic foveal neovascularization is associated with diminished subfoveal choroidal flow on optical coherence tomography angiography.Eye (London, England) · 2025Article
- Retinal vessel tortuosity and fractal dimension in diabetic retinopathy.International journal of retina and vitreous · 2025Article
- Effect of panretinal photocoagulation versus intravitreal bevacizumab injection on optic disc microcirculation in patients with diabetic retinopathy.International journal of retina and vitreous · 2024Article
- Differential Capillary and Large Vessel Analysis Improves OCTA Classification of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2024Article
- Article
- Is There a Nonperfusion Threshold on OCT Angiography Associated With New Vessels Detected on Ultra-Wide-Field Imaging in Diabetic Retinopathy?Translational vision science & technology · 2023Article
- Hybrid Fusion of High-Resolution and Ultra-Widefield OCTA Acquisitions for the Automatic Diagnosis of Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2023Article
- Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses.Translational vision science & technology · 2023Observational
- Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review.Journal of ophthalmology · 2023Review
- Article
- Diabetic macular ischaemia- a new therapeutic target?Progress in retinal and eye research · 2022Review
- Perspectives on diabetic retinopathy from advanced retinal vascular imaging.Eye (London, England) · 2022Review
- Differentiating features of OCT angiography in diabetic macular edema.Scientific reports · 2021Article
- Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy.Journal of clinical medicine · 2021Article
- Evaluation of Foveal Vasculature by Optical Coherence Tomography Angiography after Pan-Retinal Photocoagulation versus Intravitreal Anti-VEGF Injections.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo quantify vessel tortuosity and fractal dimension of the superficial capillary plexus (SCP) of the macula in different stages of diabetic retinopathy (DR), and following panretinal photocoagulation (PRP) using optical coherence tomography angiography (OCTA).
methods75 eyes of 75 subjects were divided into five groups; healthy controls, diabetes with no clinical DR, non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR) and patients who received PRP for PDR (PDR+PRP).For vessel tortuosity, SCP slabs from 3x3 mm macular OCTA scans were processed using imageJ (NIH, USA), where large perifoveal vessels were traced and their length was measured with tortuosity calculated as the ratio between the actual length and the straight Euclidean length. For fractal dimension, SCP slabs were processed and imported to Fractalyse (ThéMA, France), where box-counting analyses produced fractal dimension values.
resultsWe found a significant difference in vessel tortuosity and fractal dimension between the five groups (one-way ANOVA, p < 0.001both). NPDR and PDR had significantly more tortuous vessels and lower fractal dimension compared to healthy controls (Tukey HSD: p = 0.02, 0.015,0.015 and <0.001, respectively). Fractal dimension was also significantly lower in NPDR and PDR compared to eyes with no clinical DR (p <0.001 both), and in PDR compared to NPDR (p = 0.014). Following PRP, vessel tortuosity was significantly lower and fractal dimension was higher in PDR+PRP compared to PDR (p = 0.001 and 0.031, respectively).
conclusionsWe used macular OCTA scans to demonstrate significantly higher perifoveal large vessel tortuosity, and lower fractal dimension in NPDR and PDR compared to healthy controls. Vessel tortuosity shows more dramatic normalization than fractal dimension and could be explored as a sensitive marker for successful PRP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.