ArticlePloS one2019
Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Microbiota-metabolite axis in endometriosis: Pathogenic mechanisms and clinical implications.Journal of biomedical research · 2026Article
- The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets.International journal of molecular sciences · 2026Review
- Immune regulatory networks and gut microbiota-associated targets in endometriosis: an integrative multi-omics and network analysis.Open life sciences · 2026Article
- Microbiota insights in endometriosis.Microbiome · 2025Review
- The Role of the Microbiome in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Impact of gut microbiota on endometriosis: linking physical injury to mental health.Frontiers in cellular and infection microbiology · 2025Review
- Review
- Cardio-Metabolic Risk Profile of Women With Endometriosis: A Population-Based Study.Endocrinology, diabetes & metabolism · 2024Article
- Endometrial Dysbiosis: A Possible Association with Estrobolome Alteration.Biomolecules · 2024Article
- Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread.International journal of molecular sciences · 2024Review
- The impact of the microbiota-gut-brain axis on endometriosis-associated symptoms: mechanisms and opportunities for personalised management strategies.Reproduction & fertility · 2024Article
- Role of the gut microbiota in the pathogenesis of endometriosis: a review.Frontiers in microbiology · 2024Review
- Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis.Frontiers in cellular and infection microbiology · 2024Review
- Gut Microbiome-Estrobolome Profile in Reproductive-Age Women with Endometriosis.International journal of molecular sciences · 2023Article
- Gut and reproductive tract microbiota: Insights into the pathogenesis of endometriosis (Review).Biomedical reports · 2023Review
- Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review.Microorganisms · 2023Review
- Gut microbiota and microbiota-derived metabolites promotes endometriosis.Cell death discovery · 2023Article
- Association between gut microbiota and endometriosis: a two-sample Mendelian randomization study.Frontiers in microbiology · 2023Article
- The gut microbiota: a double-edged sword in endometriosis†.Biology of reproduction · 2022Review
- Female reproductive dysfunctions and the gut microbiota.Journal of molecular endocrinology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that there is an interaction between the gut microbiota and endometriotic lesions. The new formation of these lesions is associated with stem cell recruitment, angiogenesis and inflammation, which may affect the composition of the gut microbiota. To test this hypothesis, we herein induced endometriotic lesions by transplantation of uterine tissue fragments from green fluorescent protein (GFP)+ donor mice into the peritoneal cavity of GFP- C57BL/6 wild-type mice. Sham-transplanted animals served as controls. Fecal pellets of the animals were collected 3 days before as well as 7 and 21 days after the induction of endometriosis to analyze the composition of the gut microbiota by means of 16S ribosomal RNA gene sequencing. The transplantation of uterine tissue fragments resulted in the establishment of endometriotic lesions in all analyzed mice. These lesions exhibited a typical histomorphology with endometrial glands surrounded by a vascularized stroma. Due to their bright GFP signal, they could be easily differentiated from the surrounding GFP- host tissue. Bacterial 16S rRNA genes were successfully PCR-amplified from the DNA extracts of all obtained mice fecal samples. However, no significant effect of endometriosis induction on the composition of the bacterial microbiota was detected with our experimental setup. Our findings allow careful speculation that endometriosis in mice does not induce pronounced dysbiosis during the acute phase of lesion formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.