Evidence map›Paper›PMID 31886887›Full record

ArticleJournal of cutaneous pathology2020

Expanding the differential of superficial tumors with round-cell morphology: Report of three cases of CIC-rearranged sarcoma, a potentially under-recognized entity.

Nolan Maloney, Stephen M Smith, Sara B Peters, Anna Batistatou, Zoi Evangelou, Paul W Harms, May P Chan, Cristina R Antonescu, Konstantinos Linos

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cutaneous pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Molecular and therapeutic advancements in Capicua (Frontiers in cell and developmental biology · 2024
    Review
  7. Small round cell sarcomas.Nature reviews. Disease primers · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Nolan MaloneyDepartment of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, One Medical Center Drive, New Hampshire, Lebanon.ORCID https://orcid.org/0000-0002-4088-6497
Stephen M SmithDivision of Dermatopathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.ORCID https://orcid.org/0000-0003-0464-5087
Sara B PetersDivision of Dermatopathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Anna BatistatouDepartment of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Zoi EvangelouDepartment of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Paul W HarmsDepartment of Pathology and Dermatology, University of Michigan, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-0802-2883
May P ChanDepartment of Pathology and Dermatology, University of Michigan, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-0650-1266
Cristina R AntonescuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Konstantinos LinosDepartment of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, One Medical Center Drive, New Hampshire, Lebanon.ORCID https://orcid.org/0000-0001-9462-652X
Dartmouth–Hitchcock Medical Center · USThe Ohio State University Wexner Medical Center · USUniversity of Ioannina · GRUniversity of Michigan · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Among sarcomas with a round-cell morphology that lack rearrangement of the EWSR1 gene, rearrangements involving the CIC gene are the most common. In comparison with Ewing Sarcoma, CIC-rearranged sarcomas present at an older average age, arise almost exclusively in soft tissues, are clinically more aggressive, and are more likely to be resistant to the chemotherapy regimens used for Ewing sarcoma. CIC-rearranged sarcomas present more commonly in a deep location, and we suspect that superficial presentations may be under-recognized. In this case series, we report three of such cases. Overall, the morphology is similar to CIC-rearranged sarcomas of deeper locations. We hope to raise awareness among the dermatopathology community by expanding the differential of superficial tumors with round cell morphology.

Indexed as

12E7 AntigenAdultBone NeoplasmsFemaleGene RearrangementHigh-Throughput Nucleotide SequencingHomeodomain ProteinsHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMiddle AgedOncogene Proteins, FusionRepressor ProteinsSarcomaSarcoma, Ewing12E7 AntigenCD99 protein, humanCIC-DUX4 fusion protein, humanCIC protein, humanDUX4L1 protein, humanHomeodomain ProteinsOncogene Proteins, FusionRepressor ProteinsCICCIC-DUXCIC-DUX4CIC-rearrangedround-cell sarcoma

Identifiers

PMID31886887
PMCPMC8353993
OpenAlexW2997815119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.