Evidence map›Paper›PMID 31886717›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis.

Estibaliz Castillero, Hirokazu Akashi, Marc Najjar, Ruiping Ji, Lea Maria Brandstetter, Catherine Wang, Xianghai Liao, Xiaokan Zhang, Alexandra Sperry, Marcia Gailes and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

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  13. The integrated stress response in ischemic diseases.Cell death and differentiation · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Estibaliz CastilleroDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.ORCID 0000-0002-2213-5809
Hirokazu AkashiDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Marc NajjarDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Ruiping JiDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Lea Maria BrandstetterDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Catherine WangDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Xianghai LiaoDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Xiaokan ZhangDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Alexandra SperryDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Marcia GailesDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Karina GuamanDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Adam RechtDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Ira SchlosbergDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
H Lee SweeneyDepartment of Pharmacology, University of Florida, Gainesville, Florida.
Ziad A AliDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Shunichi HommaDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Paolo C ColomboDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Giovanni FerrariDivision of Surgical Science, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
P Christian SchulzeDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York.
Isaac GeorgeDivision of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York.
Columbia University · USUniversity of Florida · US

Funding

Supplement to Serotonin Signaling in Mitral Valve Homeostasis, Maintenance and RestorationR01HL131872 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Giovanni Ferrari, Robert J Levy · 2016 to 2026
$7.7M
Role of RAGE in Bicuspid Aortic Valve SyndromeR01HL122805 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FERRARI, GIOVANNI · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL122805NHLBI NIH HHS R01 HL131872
6 · The paper itself

Abstract

Myostatin (MSTN) is a transforming growth factor (TGF)-β superfamily member that acts as a negative regulator of muscle growth and may play a role in cardiac remodeling. We hypothesized that inhibition of activin type II receptors (ACTRII) to reduce MSTN signaling would reduce pathological cardiac remodeling in experimental heart failure (HF). C57BL/6J mice underwent left anterior descending coronary artery ligation under anesthesia to induce myocardial infarction (MI) or no ligation (sham). MI and sham animals were each randomly divided into groups (

Indexed as

Activin Receptors, Type IIAnimalsEchocardiographyFibrosisMaleMiceMice, Inbred C57BLMitogen-Activated Protein KinasesMyocardial InfarctionMyocardial IschemiaMyocardiumMyostatinNatriuretic Peptide, BrainPhosphorylationPhysical EnduranceReceptor, Transforming Growth Factor-beta Type IActivin Receptors, Type IIAtp2a2 protein, mouseMitogen-Activated Protein KinasesMyostatinNatriuretic Peptide, BrainReceptor, Transforming Growth Factor-beta Type ISarcoplasmic Reticulum Calcium-Transporting ATPasescardiac fibrosiscardiac remodelingheart failuremyocardial infarctionmyostatin

Identifiers

PMID31886717
PMCPMC7052626
OpenAlexW2997541554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.