ArticleBehavioral neuroscience2020
Sex differences in age-related impairments vary across cognitive and physical assessments in rats.
Article in Behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.Behavioral neuroscience · 2026Article
- Progressive neurodegeneration, motor decline, and premature mortality in aging Ngly1 deficient rats.Orphanet journal of rare diseases · 2026Article
- Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats.Frontiers in aging neuroscience · 2026Article
- Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice.Cell death & disease · 2025Article
- Inflammation increases the penetrance of behavioral impairment inbioRxiv : the preprint server for biology · 2025Article
- Article
- Effects of cannabis smoke and oral Δ9THC on cognition in young adult and aged rats.Psychopharmacology · 2025Article
- SORD-deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights.Brain : a journal of neurology · 2024Article
- Sex differences in spontaneous behavior and cognition in mice using an automated behavior monitoring system.Physiology & behavior · 2024Article
- Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea.Biology of sex differences · 2024Article
- Sex differences in motor learning flexibility are accompanied by sex differences in mushroom spine pruning of the mouse primary motor cortex during adolescence.Frontiers in neuroscience · 2024Article
- Article
- Microbiome-driven alterations in metabolic pathways and impaired cognition in aged female TgF344-AD rats.Aging brain · 2024Article
- Gestational ethanol exposure impairs motor skills in female mice through dysregulated striatal dopamine and acetylcholine function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice.Neurobiology of aging · 2023Article
- Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers.Addiction neuroscience · 2023Article
- Four-parameter analysis in modified Rotarod test for detecting minor motor deficits in mice.BMC biology · 2023Article
- RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease.The European journal of neuroscience · 2023Article
- Cognitive mechanisms underlying decision making involving risk of explicit punishment in male and female rats.Cognitive, affective & behavioral neuroscience · 2023Article
- Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats.eNeuro · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Inclusion of female subjects in preclinical biomedical research is imperative for understanding mechanisms of age-related cognitive decline, as more than half of individuals older than 65 are female. In rodents, however, few behavioral and physical assessments have been conducted in both sexes within the same study. The current article documents data obtained from young and aged rats of both sexes that performed a battery of cognitive and physical assessments to examine for potential interactions between sex and age. Physical performance was measured with a rotarod test of motor coordination, assessment of maximum grip strength, and swim speed. While females outperformed males in rotarod and grip strength, there was also an age-dependent decline in physical performance in both sexes. Cognitive assessments included the Morris watermaze test of hippocampal dependent spatial memory and a biconditional association task with a working memory (WM) component, both of which were not significantly different across sex. Notably, a cognitive dual task that simultaneously tests working memory (WM) and biconditional association task (BAT) acquisition has previously been shown to be more sensitive to age-related cognitive decline than the watermaze in male rats, which is replicated here in both female and male rats. Furthermore, young and aged females (<27 months) spent a similar percent of time in each estrus cycle phase and phase did not influence WM/BAT performance. Future studies utilizing similar behavioral paradigms to examine the neurobiology of cognitive aging should be representative of the human population they intend to model through the inclusion of female subjects. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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