Evidence map›Paper›PMID 31886682›Full record

ArticlePsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2020

Early substance use in the pathway from childhood attention-deficit/hyperactivity disorder (ADHD) to young adult substance use: Evidence of statistical mediation and substance specificity.

Andrea L Howard, Traci M Kennedy, John T Mitchell, Margaret H Sibley, Stephen P Hinshaw, L Eugene Arnold, Arunima Roy, Annamarie Stehli, James M Swanson, Brooke S G Molina

Open access · hybridAbstract read
In one paragraph

Article in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Frontiers in neuroscience · 2023
    Article
  9. Frontiers in psychiatry · 2023
    Article
  10. Article
  11. Review
  12. Review
  13. Methods to Develop anFrontiers in psychiatry · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea L HowardDepartment of Psychology.ORCID 0000-0002-9843-9577
Traci M KennedyDepartment of Psychiatry.
John T MitchellDepartment of Psychiatry and Behavioral Sciences.
Margaret H SibleyDepartment of Psychiatry.
Stephen P HinshawDepartment of Psychology.
L Eugene ArnoldDepartment of Psychiatry and Behavioral Health.
Arunima RoyDepartment of Cellular and Molecular Medicine.
Annamarie StehliDepartment of Pediatrics.
James M SwansonDepartment of Pediatrics.
Brooke S G MolinaDepartment of Psychiatry.

Funding

Pathways to adult substance use and abuse from childhood ADHD in the MTAR01DA039881 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2015 to 2018
$1.1M
MULTISITE MULTIMODALITY TREATMENT STUDY OF ADHD/ADDU01MH050440 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI SWANSON, JAMES M · 1992 to 2000
$17k
MULTISITE MULTIMODAL TREATMENT STUDY OF ADHD/ADDU01MH050453 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD B · 1992 to 2000
$17k
PHARMACOLOGIC AND PSYCHOSOCIAL INTERVENTIONS FOR ADHDU01MH050461 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HINSHAW, STEPHEN P · 1992 to 2000
$17k
PHARMACOLOGICAL AND PSYCHOSOCIAL TREATMENT FOR ADHDU01MH050467 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PELHAM, WILLIAM E · 1992 to 2000
$17k
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012011N01MH012011 · NIMH · UNIVERSITY OF CALIFORNIA, IRVI · PI SWANSON, JAMES · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012004N01MH012004 · NIMH · NEW YORK UNIVERSITY SCHOOL OF · PI ABIKOFF, HOWARD BARRY · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
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FOLLOW UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012007N01MH012007 · NIMH · RES. FOUND. FOR MENTAL HEALTH, · PI GREENHILL, LARRY LEE · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012008N01MH012008 · NIMH · MCGILL UNIVERSITY · PI HECHTMAN, LILY T. · 2002 to 2006
–
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012009N01MH012009 · NIMH · UNIVERSITY OF CALIFORNIA, BERK · PI HINSHAW, STEPHEN · 2002 to 2006
–
FOLLOW UP OF THE MULTIMODAL TREATMETN STUDY OF CHILDREN WITH ATTENTION-278012010N01MH012010 · NIMH · UNIVERSITY OF PITTSBURGH · PI SG MOLINA, BROOKE · 2002 to 2006
–
Alexander von Humboldt FoundationNIDA NIH HHS R01 DA039881NIMH NIH HHS N01 MH012004NIMH NIH HHS N01 MH012007NIMH NIH HHS N01 MH012008NIMH NIH HHS N01 MH012009NIMH NIH HHS N01 MH012010NIMH NIH HHS N01 MH012011NIMH NIH HHS N01 MH012012NIMH NIH HHS U01 MH050440NIMH NIH HHS U01 MH050453NIMH NIH HHS U01 MH050461NIMH NIH HHS U01 MH050467University of Pittsburgh
6 · The paper itself

Abstract

This study tested whether early and developmentally atypical substance use mediates risk for adult substance use among children with attention-deficit/hyperactivity disorder (ADHD), and whether that risk is substance-specific. Participants were children with ADHD previously enrolled in a randomized controlled trial (RCT), and a demographically similar non-ADHD group, assessed at 2 through 16 years after the original RCT baseline. Self-reports of heavy drinking, marijuana use, daily smoking, and other illicit drug use were collected at follow-ups to establish atypically early and frequent use. Models estimated statistically mediated effects of childhood ADHD on adult substance use via early substance involvement, with planned comparisons to evaluate substance specificity. Results supported the mediation hypothesis, showing that childhood ADHD was associated with more frequent adult substance use via early substance involvement for marijuana, cigarettes, illicit drugs, and to a lesser extent, alcohol. Mediation was not escalated by comorbid childhood conduct disorder or oppositional defiant disorder except for early use of nonmarijuana illicit drugs. Substance-specificity in the mediational pathway was largely absent except for cigarette use, where ADHD-related early smoking most strongly predicted adult daily smoking. Findings from this study provide new evidence that atypically early substance use associated with childhood ADHD signals important cross-drug vulnerability by early adulthood, but cigarette use at a young age is especially associated with increased risk for habitual (daily) smoking specifically. Efforts to prevent, delay, or reduce substance experimentation should occur early and focus on factors relevant to multiple drugs of abuse in this at-risk population. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityChildFemaleHumansMaleRandomized Controlled Trials as TopicSubstance-Related DisordersYoung Adult

Identifiers

PMID31886682
PMCPMC9812258
OpenAlexW2998171211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.