Evidence map›Paper›PMID 31886591›Full record

Trial reportThe International journal of pharmacy practice2020

Effect of a pharmacist-led intervention on adherence among patients with a first-time prescription for a cardiovascular medicine: a randomized controlled trial in Norwegian pharmacies.

Ragnar Hovland, Sara Bremer, Christine Frigaard, Solveig Henjum, Per Kristian Faksvåg, Erik Magnus Saether, Ivar Sønbø Kristiansen

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The International journal of pharmacy practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ragnar HovlandApokus, National Centre for Development of Pharmacy Practice, Oslo, Norway.ORCID https://orcid.org/0000-0001-9084-5821
Sara BremerApokus, National Centre for Development of Pharmacy Practice, Oslo, Norway.ORCID https://orcid.org/0000-0002-7380-2798
Christine FrigaardApokus, National Centre for Development of Pharmacy Practice, Oslo, Norway.
Solveig HenjumNorwegian Pharmacy Association, Oslo, Norway.
Per Kristian FaksvågNorwegian Pharmacy Association, Oslo, Norway.
Erik Magnus SaetherOslo Economics, Oslo, Norway.
Ivar Sønbø KristiansenOslo Economics, Oslo, Norway.
Norwegian Pharmacy Association · NO657 Oslo · NOUniversity of Oslo · NO

Funding

The Norwegian Community Pharmacy FoundationThe Norwegian Pharmacy Association
6 · The paper itself

Abstract

objectiveTo examine whether a pharmacist-led intervention improves medication adherence among patients who have filled a first-time prescription for a cardiovascular medicine.

methodsDesign: Unblinded randomized controlled trial.

setting67 Norwegian pharmacies, October 2014-June 2015.

participants1480 adults with a first-time prescription for a cardiovascular medicine.

interventionParticipants in the intervention group received two consultations with a pharmacist 1-2 and 3-5 weeks after filling the prescription. Participants in the control group received care according to usual practice.

main outcome measureThe primary outcome was self-reported adherence as measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), at 7 and 18 weeks after filling the prescription. Adherence from baseline to week 52 was estimated using data from the Norwegian Prescription Database (NPD). KEY

findingsData from MMAS-8 showed that 91.3% of the patients in the intervention group were adherent after 7 weeks versus 86.8% in the control group (4.5% difference, 95% CI 0.8-8.2, P = 0.017). The corresponding proportions were 88.7% versus 83.7% after 18 weeks (5.0% difference, 95% CI 0.8-9.2, P = 0.021). NPD data (n = 1294) showed no significant difference in adherence after 52 weeks (95% CI -2.0 to 7.8, P = 0.24). However, adherence among statin users (n = 182) was 66.5% in the intervention group versus 57.4% among new statin users in the general population (n = 1500) (difference 9.1%, 95% CI 1.5-16.0, P = 0.019).

conclusionThe main outcome measure indicates that a short, structured pharmacist-led intervention may increase medication adherence for patients starting on chronic cardiovascular medication. However, these findings could not be confirmed by the NPD data analysis.

Indexed as

Medication AdherencePharmacistsAdultAgedCardiovascular DiseasesFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePharmaciescardiovascular diseasecommunity pharmacyhospital pharmacymedication adherencepharmacist-led intervention

Identifiers

PMID31886591
PMCPMC7384053
OpenAlexW2997515954

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.