Does early cognitive decline require the presence of both tau and amyloid-β?

Michael Schöll, Anne Maass

Erratum issuedAbstract readComment

In one paragraph

Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

A unique color-coded visualization system with multimodal information fusion and deep learning in a longitudinal study of Alzheimer's disease.Artificial intelligence in medicine · 2023
Article
Content-specific vulnerability of recent episodic memories in Alzheimer's disease.Neuropsychologia · 2021
Article
Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
Article
Current advances in digital cognitive assessment for preclinical Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
Review
Interactive rather than independent effect ofBrain communications · 2021
Article
PET Imaging of Tau Pathology and Amyloid-β, and MRI for Alzheimer's Disease Feature Fusion and Multimodal Classification.Journal of Alzheimer's disease : JAD · 2021
Article
Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.Scientific reports · 2020
Article

4 · The record

Corrections and comments

Comment on
Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age.2020
Erratum issued
Erratum.2020

5 · Who and what money

Authors and funding

2 authors.

Michael SchöllWallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden.

Anne MaassGerman Center for Neurodegenerative Diseases, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cognitive DysfunctionBiomarkersHumansMiddle Agedtau ProteinsBiomarkerstau Proteins

Identifiers

PMID31886490

DOI10.1093/brain/awz399

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.