Evidence map›Paper›PMID 31886488›Full record

ArticleBiostatistics (Oxford, England)2021

Adaptive group-regularized logistic elastic net regression.

Magnus M Münch, Carel F W Peeters, Aad W Van Der Vaart, Mark A Van De Wiel

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial intelligence to investigate metabolomics data for precision medicine.Metabolomics : Official journal of the Metabolomic Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fast Marginal Likelihood Estimation of Penalties for Group-Adaptive Elastic Net.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2023
    Article
  10. Semi-supervised empirical Bayes group-regularized factor regression.Biometrical journal. Biometrische Zeitschrift · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Magnus M MünchDepartment of Epidemiology & Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, PO Box 7057, 1007 MB Amsterdam, The Netherlands and Mathematical Institute, Leiden University, PO Box 9512, 2300 RA Leiden, The Netherlands.
Carel F W PeetersDepartment of Epidemiology & Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Aad W Van Der VaartMathematical Institute, Leiden University, PO Box 9512, 2300 RA Leiden, The Netherlands.
Mark A Van De WielDepartment of Epidemiology & Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, PO Box 7057, 1007 MB Amsterdam, The Netherlands and MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In high-dimensional data settings, additional information on the features is often available. Examples of such external information in omics research are: (i) $p$-values from a previous study and (ii) omics annotation. The inclusion of this information in the analysis may enhance classification performance and feature selection but is not straightforward. We propose a group-regularized (logistic) elastic net regression method, where each penalty parameter corresponds to a group of features based on the external information. The method, termed gren, makes use of the Bayesian formulation of logistic elastic net regression to estimate both the model and penalty parameters in an approximate empirical-variational Bayes framework. Simulations and applications to three cancer genomics studies and one Alzheimer metabolomics study show that, if the partitioning of the features is informative, classification performance, and feature selection are indeed enhanced.

Indexed as

GenomicsNeoplasmsBayes TheoremHumansLogistic ModelsRegression AnalysisEmpirical BayesHigh-dimensional dataPredictionVariational Bayes

Identifiers

PMID31886488
PMCPMC8596493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.