ArticleBrain communications2019
Increased weighting on prior knowledge in Lewy body-associated visual hallucinations.
Article in Brain communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Selective 5HT3 antagonists and sensory processing: a systematic review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations.NeuroImage. Clinical · 2022Pooled it
- Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Individual threat-relevance accelerates belief-updating in conditioned hallucinations.Scientific reports · 2026Article
- Hallucination Proneness is Linked to Over-Reliance on Internal Priors for Noisy Speech.Schizophrenia bulletin · 2026Article
- Cortical gradient compression links cognition and transcriptomic signatures in primary angle-closure glaucoma.Communications biology · 2026Article
- Engineering Pareidolia: Mental Imagery, Perceptual Scaffolding, and Visual Creativity.Brain sciences · 2026Article
- Neural and computational mechanisms underlying one-shot perceptual learning in humans.Nature communications · 2026Article
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Conscious vision: investigating visual hallucination awareness in Lewy body disease.Brain communications · 2026Article
- Disrupted visual-to-semantic dynamics promote visual hallucinations in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Refining mechanistic models of hallucinations for enhanced translatability.Translational psychiatry · 2025Review
- Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Motor Functional Hierarchical Organization of Cerebrum and Its Underlying Genetic Architecture in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- When perception meets grief: how the brain reconstructs person networks in response to absence.Social cognitive and affective neuroscience · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Disrupted functional brain network associated with presence of hallucinations in Parkinson's disease.Brain communications · 2025Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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Abstract
Hallucinations are a common and distressing feature of many psychiatric and neurodegenerative conditions. In Lewy body disease, visual hallucinations are a defining feature, associated with worse outcomes; yet their mechanisms remain unclear and treatment options are limited. Here, we show that hallucinations in Lewy body disease are associated with altered integration of top-down predictions with incoming sensory evidence, specifically with an increased relative weighting of prior knowledge. We tested 37 individuals with Lewy body disease, 17 habitual hallucinators and 20 without hallucinations, and 20 age-matched healthy individuals. We employed an image-based learning paradigm to test whether people with Lewy body disease and visual hallucinations show higher dependence on prior knowledge. We used two-tone images that are difficult to disambiguate without any prior information but generate a strong percept when information is provided. We measured discrimination sensitivity before and after this information was provided. We observed that in people with Lewy body disease who experience hallucinations, there was greater improvement in discrimination sensitivity after information was provided, compared to non-hallucinators and controls. This suggests that people with Lewy body disease and hallucinations place higher relative weighting on prior knowledge than those who do not hallucinate. Importantly, increased severity of visual hallucinations was associated with an increased effect of prior knowledge. Together these findings suggest that visual hallucinations in Lewy body disease are linked to a shift towards top-down influences on perception and away from sensory evidence, perhaps due to an increase in sensory noise. This provides important mechanistic insights to how hallucinations develop in Lewy body disease, with potential for revealing new therapeutic targets.
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