Evidence map›Paper›PMID 31886419›Full record

ArticleClinical and translational radiation oncology2020

High versus low dose Stereotactic Body Radiation Therapy for hepatic metastases.

Esther N D Kok, Edwin P M Jansen, Birthe C Heeres, Niels F M Kok, Tomas Janssen, Erik van Werkhoven, Fay R K Sanders, Theodore J M Ruers, Marlies E Nowee, Koert F D Kuhlmann

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Stereotactic radiotherapy for liver oligometastases.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  13. Use of Multi-Site Radiation Therapy for Systemic Disease Control.International journal of radiation oncology, biology, physics · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Esther N D KokDepartment of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Edwin P M JansenDepartment of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Birthe C HeeresDepartment of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Niels F M KokDepartment of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Tomas JanssenDepartment of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Erik van WerkhovenMedical Biostatistics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Fay R K SandersDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Theodore J M RuersDepartment of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marlies E NoweeDepartment of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Koert F D KuhlmannDepartment of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
The Netherlands Cancer Institute · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStereotactic Body Radiation Therapy (SBRT) is a treatment option for patients with liver metastases. This study evaluated the impact of high versus low dose image-guided SBRT of hepatic metastases. METHODS AND MATERIALS: This is a single-center retrospective study of patients with liver metastases treated with SBRT. For analyses, patients were divided into two groups: ≤100 Gy and >100 Gy near-minimum Biological Effective Doses (BED

resultsNinety patients with 97 liver metastases (77% colorectal) were included. Median follow-up was 28.6 months. The two-year LC rates in the ≤100 Gy and >100 Gy BED

conclusionHigh dose SBRT provides significantly better local control and overall survival than low dose SBRT without increasing toxicity. When surgical resection is not feasible, high dose SBRT provides an effective and safe treatment for liver metastases.

Indexed as

Dose-escalationLiver metastasesLocal controlSBRTStereotactic Body Radiation Therapy

Identifiers

PMID31886419
PMCPMC6906721
OpenAlexW2990637329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.