ArticleJournal of immunology research2019
Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels.
Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Immunochemical Determination of IgE and IgG Autoantibodies in Patients with Chronic Spontaneous Urticaria: A Narrative Review.Antibodies (Basel, Switzerland) · 2026Review
- Clinical phenotypes and molecular endotypes of chronic urticaria: Linking clinical expression to underlying immune mechanisms.Asia Pacific allergy · 2026Review
- Association between circulating thyroperoxidase (TPO), anti-TPO IgE, anti-TPO IgG, and different clinical outcomes in chronic urticaria: A hypothesis-generating study.The World Allergy Organization journal · 2025Article
- Autoallergy and what the Allergist Needs to know.Current allergy and asthma reports · 2025Review
- Diagnostic workup in paradoxical urticaria induced by H1-antihistamines.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Clinical and molecular aspects of managing chronic spontaneous urticaria: identifying endotypes, phenotypes, and determinants of treatment response and resistance.Frontiers in allergy · 2025Review
- Distinct Clinical Profiles of IgE and IgG Autoantibodies to Thyroid Peroxidase in Chronic Spontaneous Urticaria.Allergy, asthma & immunology research · 2024Article
- Molecular characteristics of atopic dermatitis patients with clinical remission.The World Allergy Organization journal · 2024Article
- Research hotspots in urticaria: A bibliometric study of the top 100 most cited articles.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Risk calculator of the clinical response to antihistamines in chronic urticaria: Development and internal validation.PloS one · 2024Article
- Atopy in chronic urticaria: an important yet overlooked issue.Frontiers in immunology · 2024Review
- Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade.International journal of molecular sciences · 2023Article
- In chronic spontaneous urticaria, IgE and C-reactive protein are linked to distinct microRNAs and interleukin-31.Clinical and translational allergy · 2023Article
- Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems.International journal of molecular sciences · 2023Review
- Determining the relationship between the knowledge on self-management and levels of asthma control among adult asthmatic patients: a cross-sectional study.Journal of medicine and life · 2023Article
- Immunoglobulin E and G autoantibodies against eosinophil proteins in children and adults with asthma and healthy subjects.The World Allergy Organization journal · 2023Article
- Article
- Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone.The World Allergy Organization journal · 2022Article
- The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.Frontiers in immunology · 2022Review
- Presence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis.Allergy, asthma & immunology research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics.
objectiveTo explore the clinical characteristics of CSU patients, according to the presence of anti-TPO IgE in serum.
methodsAnti-TPO IgE levels were measured during the clinical control period (Urticaria Activity Score, 0 point) and exacerbation period (≥3 points) in 100 CSU patients. Patients with self-reported exacerbation of skin involvement by foods, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical triggers underwent controlled challenge tests.
resultsWe identified 2 groups of patients: (1) patients with anti-TPO IgE during the clinical control period or during an exacerbation, who had a higher frequency of atopy, asthma, and positive challenge test results with NSAIDs and (2) patients without anti-TPO IgE during any period, who had a higher frequency of positive challenge test results for inducible urticaria. Among the first group (anti-TPO IgE at any point), we identified 3 subgroups: patients with anti-TPO IgE during the clinical control period (
conclusionAnti-TPO IgE is a useful biomarker for differentiating between clinical phenotypes of patients with CSU. Elevation of anti-TPO IgE during exacerbation periods supports an association between this autoantibody and the pathogenesis of urticaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.