Evidence map›Paper›PMID 31886298›Full record

ArticleJournal of immunology research2019

Functional Polymorphisms and Gene Expression of TLR9 Gene as Protective Factors for Nasopharyngeal Carcinoma Severity and Progression.

Macherki Yosra, Souissi Sameh, Ghedira Randa, Remadi Yassmine, Gabbouj Sallouha, Bouzid Nadia, Bouaouina Noureddine, Zakhama Abdelfattah, Hassen Elham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Impact ofBiomolecules & biomedicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Macherki YosraLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Souissi SamehLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Ghedira RandaLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.ORCID https://orcid.org/0000-0002-8610-354X
Remadi YassmineLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Gabbouj SallouhaLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Bouzid NadiaLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Bouaouina NoureddineLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Zakhama AbdelfattahLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.
Hassen ElhamLaboratory of Molecular Immuno-Oncology, Faculty of Medicine of Monastir, Monastir University, 5019 Monastir, Tunisia.ORCID https://orcid.org/0000-0002-4195-0091
University of Monastir · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a disease that is closely associated with EBV infection. Toll-like receptor 9 is an important factor mediating the interaction between EBV and the host immune response. Any genetic (single nucleotide polymorphisms, SNPs) or expression variation in TLR9 gene may modify the ability of the receptor to respond correctly to viral infection as in NPC. This study is aimed at evaluating the effect of TLR9 functional polymorphisms (TLR9-1486 T/C and TLR9-1237 T/C) and TLR9 mRNA expression in NPC severity and progression at diagnosis and after treatment. This study included 322 patients with NPC. RFLP-PCR and real-time PCR were used to assess, respectively, the genotypes and the mRNA expression of TLR9 gene. The genotyping analysis showed that the presence of mutated allele -1237C (TLR9-1237 TC+CC) was associated with large tumor size (

Indexed as

Gene ExpressionGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overAllelesChildDisease ProgressionFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedTLR9 protein, humanToll-Like Receptor 9

Identifiers

PMID31886298
PMCPMC6899320
OpenAlexW2989714144

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.