Evidence map›Paper›PMID 31886259›Full record

ReviewBioMed research international2019

Application of Computational Biology and Artificial Intelligence Technologies in Cancer Precision Drug Discovery.

Nagasundaram Nagarajan, Edward K Y Yapp, Nguyen Quoc Khanh Le, Balu Kamaraj, Abeer Mohammed Al-Subaie, Hui-Yuan Yeh

Abstract readReview
In one paragraph

Review in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Artificial intelligence (AI) and big data in cancer and precision oncology.Computational and structural biotechnology journal · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nagasundaram NagarajanSchool of Humanities, Nanyang Technological University, 14 Nanyang Dr, Singapore 637332.ORCID https://orcid.org/0000-0002-9581-4781
Edward K Y YappSingapore Institute of Manufacturing Technology, 2 Fusionopolis Way, Singapore 138634.
Nguyen Quoc Khanh LeSchool of Humanities, Nanyang Technological University, 14 Nanyang Dr, Singapore 637332.
Balu KamarajDepartment of Neuroscience Technology, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Jubail 35816, Saudi Arabia.
Abeer Mohammed Al-SubaieDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Hui-Yuan YehSchool of Humanities, Nanyang Technological University, 14 Nanyang Dr, Singapore 637332.ORCID https://orcid.org/0000-0002-4822-2919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare including research and chemical discoveries. Using large amounts of aggregated data, the AI can discover and learn further transforming these data into "usable" knowledge. Being well aware of this, the world's leading pharmaceutical companies have already begun to use artificial intelligence to improve their research regarding new drugs. The goal is to exploit modern computational biology and machine learning systems to predict the molecular behaviour and the likelihood of getting a useful drug, thus saving time and money on unnecessary tests. Clinical studies, electronic medical records, high-resolution medical images, and genomic profiles can be used as resources to aid drug development. Pharmaceutical and medical researchers have extensive data sets that can be analyzed by strong AI systems. This review focused on how computational biology and artificial intelligence technologies can be implemented by integrating the knowledge of cancer drugs, drug resistance, next-generation sequencing, genetic variants, and structural biology in the cancer precision drug discovery.

Indexed as

Artificial IntelligenceComputational BiologyDrug DiscoveryPrecision MedicineAlgorithmsHumansNeoplasms

Identifiers

PMID31886259
PMCPMC6925679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.