Evidence map›Paper›PMID 31886257›Full record

ArticleBioMed research international2019

The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21.

Xiaona Xu, Zhiqiang Zhao, Guangping Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xiaona XuTianjin Key Laboratory of Ionic-Molecular Function of Caidiovascular Disease, Department of Cardiology, Tianjin Instiute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.ORCID https://orcid.org/0000-0003-2500-2689
Zhiqiang ZhaoTianjin Key Laboratory of Ionic-Molecular Function of Caidiovascular Disease, Department of Cardiology, Tianjin Instiute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Guangping LiTianjin Key Laboratory of Ionic-Molecular Function of Caidiovascular Disease, Department of Cardiology, Tianjin Instiute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.ORCID https://orcid.org/0000-0003-2121-2873
Second Hospital of Tianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular calcification is an independent risk factor for plaque instability and is associated with endothelial cell function. Here, we investigated the role of endothelial cell function in the calcification of atherosclerotic plaques. We hypothesized that atherosclerosis would be associated with endothelial dysfunction and that bosentan (Tracleer®), a dual endothelin-receptor antagonist, would preserve endothelial cell function in an apolipoprotein E-deficient (ApoE

Indexed as

AnimalsAorta, ThoracicApolipoproteins EApoptosis Regulatory ProteinsAtherosclerosisbcl-2-Associated X ProteinBody WeightBosentanCaspase 3Diet, High-FatLipidsMiceMice, Inbred C57BLMicroRNAsProtective AgentsRNA-Binding ProteinsApolipoproteins EApoptosis Regulatory Proteinsbcl-2-Associated X ProteinBosentanCaspase 3LipidsMicroRNAsMIRN21 microRNA, mousePdcd4 protein, mouseProtective AgentsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID31886257
PMCPMC6915145
OpenAlexW2993896282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.