Evidence map›Paper›PMID 31886227›Full record

ArticleBioMed research international2019

Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGF

Shufen Liu, Yuhao Cheng, Yuqi Tan, Jingcheng Dong, Qin Bian

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Shufen LiuLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuhao ChengInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuqi TanInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jingcheng DongThe Institutes of Integrative Medicine, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5194-367X
Qin BianThe Institutes of Integrative Medicine, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7283-0132
Fudan University · CNJohns Hopkins University · USShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAberrant transforming growth factor

designLIG was injected to the lumbar spinal instability (LSI) mouse model. The effect of LIG was evaluated by intervertebral disc (IVD) score in the LSI mouse model. The expression of activated TGF

resultsIVD score and the percentage of pSmad2/3+ NP cells were low in LIG-treated LSI mice in comparison with LSI mice, but close to the levels in the Sham group. Similarly, LIG reduced the overexpression of TGF

conclusionsLIG prevents IDD via suppression of TGF

Indexed as

Nucleus PulposusAnimalsHumansIntervertebral Disc DegenerationMaleMiceMice, Inbred C57BLPyrazinesRatsRats, Sprague-DawleyTransforming Growth Factor betaPyrazinestetramethylpyrazineTransforming Growth Factor beta

Identifiers

PMID31886227
PMCPMC6914881
OpenAlexW2992606135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.