Evidence map›Paper›PMID 31886106›Full record

ReviewAlcohol research : current reviews2019

Co-Occurring Alcohol Use Disorder and Anxiety: Bridging Psychiatric, Psychological, and Neurobiological Perspectives.

Justin J Anker, Matt G Kushner

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alcohol research : current reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06793488 (Neural Mechanisms of Anxiety During Early and Protracted Abstinence in Alcohol Use Disorder), which is not on this map. Cited by 87 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06793488 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Neural Mechanisms of Anxiety During Early and Protracted Abstinence in Alcohol Use Disorder

TypeinterventionalSponsorColumbia UniversityRan2025 to 2029Enrolled60ConditionsAlcohol Use DisorderArmsDisulfiram 250 mg, functional MRI
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Sex-Based Mechanisms of Stress-Induced Alcohol-Seeking.Behavioral sciences (Basel, Switzerland) · 2026
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  17. Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Justin J AnkerJustin J. Anker, Ph.D., is an assistant professor in the Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Matt G KushnerMatt G. Kushner, Ph.D., is a professor in the Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.

Funding

Dismantling the Components and Dosing of CBT for Co-Occurring DisordersR01AA015069 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KUSHNER, MATT G · 2005 to 2018
$3.8M
Physiological Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use OutcomesK01AA024805 · NIAAA · UNIVERSITY OF MINNESOTA · PI ANKER, JUSTIN JACK · 2017 to 2021
$726k
NIAAA NIH HHS K01 AA024805NIAAA NIH HHS R01 AA015069
6 · The paper itself

Abstract

A substantial number of people who have problems with alcohol also experience strong anxiety and mood problems. This article provides an overview of the evolving perspectives of this association in the context of three related disciplines-psychiatry, psychology, and neuroscience. Psychiatric and epidemiological studies show that having either an anxiety- or alcohol-related diagnosis elevates the prospective risk for developing the other disorder. From the psychological perspective, behavioral research demonstrates that drinking to cope with negative affect is a potent marker for current and future problems with alcohol. Neuroscientific research implicates overlapping neurobiological systems and psychological processes in promoting the rise of negative affect and alcohol misuse. The psychiatric perspective that alcohol misuse and co-occurring anxiety represent neurobiologically distinct diagnostic conditions has dominated the field for many decades. However, recent research provides increasing support for the neuroscientific perspective that these conditions share underlying, mutually exacerbating, neurobiological processes.

Indexed as

Alcohol DrinkingAlcoholismAnxietyComorbidityDepressionHumansNervous System Diseasesalcoholanxietycomorbiditynegative affectstress

Identifiers

PMID31886106
PMCPMC6927748

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.