Evidence map›Paper›PMID 31886105›Full record

ReviewAlcohol research : current reviews2019

Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder.

Luke Archibald, Mary F Brunette, Diana J Wallin, Alan I Green

Abstract readReview
In one paragraph

Review in Alcohol research : current reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luke ArchibaldLuke Archibald, M.D., is an assistant professor in the Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Mary F BrunetteMary F. Brunette, M.D., is an associate professor in the Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Diana J WallinDiana J. Wallin, Ph.D., is a postdoctoral fellow in the Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Alan I GreenAlan I. Green, M.D., is the Raymond Sobel Professor of Psychiatry, a professor in the Department of Molecular and Systems Biology, and the chair of the Department of Psychiatry, Geisel School of Medicine at Dartmouth, as well as the director, Dartmouth Clinical and Translational Science Institute, Dartmouth College, Hanover, New Hampshire.

Funding

SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
Training in the Science of Co-Occurring DisordersT32DA037202 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2014 to 2026
$4.7M
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?R01DA034699 · NIDA · DARTMOUTH-HITCHCOCK CLINIC · PI BRUNETTE, MARY FRANCES · 2013 to 2019
$4.3M
Deconstructing Clozapine: Toward Medication for Alcoholism in SchizophreniaR01AA018151 · NIAAA · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2010 to 2011
$700k
Reward circuit dysfunction, substance use disorder and schizophrenia: a preclinical fMRI-based connectivity studyR21DA044501 · NIDA · DARTMOUTH-HITCHCOCK CLINIC · PI GREEN, ALAN I · 2017 to 2018
$446k
Alcoholism and Schizophrenia: A Translational Approach to TreatmentR21AA019534 · NIAAA · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2011 to 2012
$415k
NCATS NIH HHS UL1 TR001086NIAAA NIH HHS R01 AA018151NIAAA NIH HHS R21 AA019534NIDA NIH HHS R01 DA034699NIDA NIH HHS R21 DA044501NIDA NIH HHS T32 DA037202
6 · The paper itself

Abstract

Schizophrenia and schizoaffective disorder are schizophrenia spectrum disorders that cause significant disability. Among individuals who have schizophrenia or schizoaffective disorder, alcohol use disorder (AUD) is common, and it contributes to worse outcomes than for those who do not have co-occurring substance use disorder. Common neurobiological mechanisms, including dysfunction in brain reward circuitry, may explain the high rates of co-occurrence of schizophrenia and AUD or other substance use disorders. Optimal treatment combines pharmacologic intervention and other therapeutic modalities to address both the psychotic disorder and AUD. Further research on the etiology of these co-occurring disorders and on treatment of affected individuals is needed.

Indexed as

Alcohol DeterrentsAlcoholismAntipsychotic AgentsComorbidityHumansPrognosisPsychotherapyPsychotic DisordersSchizophreniaAlcohol DeterrentsAntipsychotic Agentsaddictionalcoholpharmacotherapyschizoaffective disorderschizophrenia

Identifiers

PMID31886105
PMCPMC6927747

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.