Evidence map›Paper›PMID 31885957›Full record

ArticleCase reports in hematology2019

Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment.

Eleni Thodou, Maria Befani, George Triantafyllidis, Theodosia Choreftaki, George Kanellis, Nikolaos Giannakoulas

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Eleni ThodouDepartment of Pathology, Medical School, University of Thessaly, Viopolis, 41500 Larisa, Greece.ORCID https://orcid.org/0000-0003-4988-1526
Maria BefaniHematology, Private Practice, 61 Koumoundourou Str., 38221 Volos, Greece.ORCID https://orcid.org/0000-0002-7786-7468
George TriantafyllidisRadiology, Private Practice, 29 Glavani Str., 38221 Volos, Greece.
Theodosia ChoreftakiDepartment of Pathology, "G. Genimmatas", Athens General Hospital, 154 Mesogeion Ave., 11527 Athens, Greece.
George KanellisDepartment of Hematopathology, "Evangelismos", General Hospital, 45 Ypsilantou Str., 10676 Athens, Greece.
Nikolaos GiannakoulasDepartment of Hematology, Medical School, University of Thessaly, Viopolis, 41500 Larisa, Greece.
University of Thessaly · GREvangelismos Hospital · GRGeneral Hospital of Athens G. Genimatas · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. The diagnosis was performed by fine-needle aspiration (FNA) of the breast lesion and the axillary lymph nodes with rapid on-site evaluation followed by immunocytochemistry, and it was confirmed by histology. The patient after first-line chemotherapy developed relapse/refractory disease. Salvage chemotherapy regimens were applied with poor results and severe toxicity. Total remission was achieved with monotherapy of brentuximab vedotin, a novel anti-CD30-targeted antibody drug conjugate. This is a unique case of breast HL with misleading clinical presentation initially diagnosed by cytology. FNA as a minimally invasive diagnostic tool was crucial in avoiding unnecessary breast surgery and further delay of chemotherapy. It is also the first report highlighting the importance of this novel immunotherapy in the management of refractory Hodgkin lymphoma with breast involvement.

Identifiers

PMID31885957
PMCPMC6915144
OpenAlexW2993551956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.